Literature DB >> 19683930

Solution-phase parallel synthesis of substituted chalcones and their antiparasitary activity against Giardia lamblia.

Julio Montes-Avila1, Sylvia P Díaz-Camacho, Josefina Sicairos-Félix, Francisco Delgado-Vargas, I A Rivero.   

Abstract

A library of 25-membered chalcones was prepared by parallel synthesis. Substituted acetophenones and benzaldehydes were condensed using the Claisen-Schmidt base-catalyzed aldol condensation. Several chalcones showed in vitro antiparasitic activity against Giardia lamblia. The highest activity observed for the IC(50) values were 12.72, 15.05 and 15.31 microg/mL, respectively; these are potential leads for the development of antigiardial compounds.

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Year:  2009        PMID： 19683930     DOI： 10.1016/j.bmc.2009.02.052

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  8 in total

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6.  Design, synthesis and molecular docking of novel diarylcyclohexenone and diarylindazole derivatives as tubulin polymerization inhibitors.

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Journal:  J Enzyme Inhib Med Chem       Date:  2016-10-24       Impact factor: 5.051

7.  Chemoselective and metal-free reduction of α,β-unsaturated ketones by in situ produced benzeneselenol from O-(tert-butyl) Se-phenyl selenocarbonate.

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Journal:  RSC Adv       Date:  2020-09-11       Impact factor: 4.036

Review 8.  Parasitic diarrheal disease: drug development and targets.

Authors:  Amir Azam; Mudasir N Peerzada; Kamal Ahmad
Journal:  Front Microbiol       Date:  2015-10-27       Impact factor: 5.640
  8 in total

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