| Literature DB >> 19683922 |
Jeremy T Starr1, Richard J Sciotti, Debra L Hanna, Michael D Huband, Lisa M Mullins, Hongliang Cai, Jeffrey W Gage, Mandy Lockard, Mark R Rauckhorst, Robert M Owen, Manjinder S Lall, Mark Tomilo, Huifen Chen, Sandra P McCurdy, Michael R Barbachyn.
Abstract
Dual inhibitors of bacterial gyrB and parE based on a 5-(2-pyrimidinyl)-imidazo[1,2-a]pyridine template exhibited MICs (microg/mL) of 0.06-64 (Sau), 0.25-64 (MRSA), 0.06-64 (Spy), 0.06-64 (Spn), and 0.03-64 (FQR Spn). Selected examples were efficacious in mouse sepsis and lung infection models at <50mg/kg (PO dosing).Entities:
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Year: 2009 PMID： 19683922 DOI： 10.1016/j.bmcl.2009.07.141
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823