PURPOSES: To investigate patterns of progression of localized retinal nerve fibre layer (RNFL) defect on red-free fundus photographs and to quantify extents of progression in normal-tension glaucoma (NTG) patients. METHODS: Sixty-five eyes of consecutive 65 NTG patients who had shown progression of localized RNFL defect on serial red-free fundus photographs were selected for this study. Patterns of progression of localized RNFL defect on red-free fundus photographs were categorized and extents of progression were quantified. Serial assessments of disc stereophotographs and visual fields were also performed to detect progression. RESULTS: The most common pattern of progression was widening of the defect towards the macula (n=37; 56.9%) followed by deepening of the defect (n=25; 38.5%), appearance of a new defect (n=6; 9.2%), and widening of the defect away from the macula (n=5; 7.7%). Eight eyes simultaneously showed two patterns of progression. Mean angular widening of the defect towards the macula and away from the macula was 6.4+/-4.1 degrees (range: 1.1-17.1 degrees , n=37) and 3.4+/-2.1 degrees (range: 1.1-5.2 degrees , n=5), respectively. No progression was observed on the disc stereophotographs (n=65) or in the visual fields (n=55) in 64 eyes (98.5%) and 46 eyes (83.6%), respectively. CONCLUSIONS: There were four patterns of progression of localized RNFL defect. In most cases, RNFL loss proceeded temporally.
PURPOSES: To investigate patterns of progression of localized retinal nerve fibre layer (RNFL) defect on red-free fundus photographs and to quantify extents of progression in normal-tension glaucoma (NTG) patients. METHODS: Sixty-five eyes of consecutive 65 NTG patients who had shown progression of localized RNFL defect on serial red-free fundus photographs were selected for this study. Patterns of progression of localized RNFL defect on red-free fundus photographs were categorized and extents of progression were quantified. Serial assessments of disc stereophotographs and visual fields were also performed to detect progression. RESULTS: The most common pattern of progression was widening of the defect towards the macula (n=37; 56.9%) followed by deepening of the defect (n=25; 38.5%), appearance of a new defect (n=6; 9.2%), and widening of the defect away from the macula (n=5; 7.7%). Eight eyes simultaneously showed two patterns of progression. Mean angular widening of the defect towards the macula and away from the macula was 6.4+/-4.1 degrees (range: 1.1-17.1 degrees , n=37) and 3.4+/-2.1 degrees (range: 1.1-5.2 degrees , n=5), respectively. No progression was observed on the disc stereophotographs (n=65) or in the visual fields (n=55) in 64 eyes (98.5%) and 46 eyes (83.6%), respectively. CONCLUSIONS: There were four patterns of progression of localized RNFL defect. In most cases, RNFL loss proceeded temporally.
Authors: Min Hee Suh; Seok Hwan Kim; Ki Ho Park; Hyeong Gon Yu; Jang Won Huh; Dong Myung Kim Journal: Jpn J Ophthalmol Date: 2012-11-28 Impact factor: 2.447
Authors: Ha Min Kim; William E McKee; Katarzyna B Malendowicz; Abinaya A Thenappan; Emmanouil Tsamis; Melvi D Eguia; C Gustavo De Moraes; Robert Ritch; Donald C Hood Journal: J Glaucoma Date: 2020-10 Impact factor: 2.290