Bo Ram Seol1,2, Byeong Wook Yoo3, Young Kook Kim2, Jin Wook Jeoung2, Ki Ho Park4. 1. Department of Ophthalmology, Veterans Health Service (VHS) Medical Center, Seoul, Republic of Korea. 2. Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Chongno-gu, Seoul, 110-744, Republic of Korea. 3. Interdisciplinary Program, Bioengineering Major, Graduate School, Seoul National University, Seoul, Republic of Korea. 4. Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Chongno-gu, Seoul, 110-744, Republic of Korea. kihopark@snu.ac.kr.
Abstract
PURPOSE: To compare the changes in macular ganglion cell-inner plexiform layer (GCIPL) defect between stable and progression primary open-angle glaucoma (POAG) groups. STUDY DESIGN: Retrospective observational study. METHODS: A total of 100 POAG eyes with localized retinal nerve fiber layer (RNFL) defect and corresponding macular GCIPL defect were selected for this study. Glaucoma progression was defined by either structural or functional deterioration. The number of abnormal superpixels on macular GCIPL deviation maps was calculated using a customized MATLAB program. GCIPL defect change was evaluated in two aspects: increased angular width and increased area. The defect patterns were categorized and compared between the stable and progression groups. RESULTS: The increase rate of angular width of GCIPL defect was higher in the progression group than in the stable group (P = 0.029). In respect to the area of GCIPL defect, there was no statistically significant differences between the groups (P = 0.227). Twenty-seven (27) of 100 (27.0%) eyes showed increased angular width of GCIPL defect. It was more frequent in the progression group than in the stable group (P = 0.043). Seventeen (17) of 27 (63.0%) eyes showed the away from the horizontal temporal raphe type progression and it was the most common change pattern of angular width of GCIPL defect. CONCLUSIONS: Increased angular width of GCIPL defect was the more prominent feature of change, and was more frequent in the progression group than in the stable group. Among the types of GCIPL defect classified, the away from the horizontal temporal raphe type was the most common.
PURPOSE: To compare the changes in macular ganglion cell-inner plexiform layer (GCIPL) defect between stable and progression primary open-angle glaucoma (POAG) groups. STUDY DESIGN: Retrospective observational study. METHODS: A total of 100 POAG eyes with localized retinal nerve fiber layer (RNFL) defect and corresponding macular GCIPL defect were selected for this study. Glaucoma progression was defined by either structural or functional deterioration. The number of abnormal superpixels on macular GCIPL deviation maps was calculated using a customized MATLAB program. GCIPL defect change was evaluated in two aspects: increased angular width and increased area. The defect patterns were categorized and compared between the stable and progression groups. RESULTS: The increase rate of angular width of GCIPL defect was higher in the progression group than in the stable group (P = 0.029). In respect to the area of GCIPL defect, there was no statistically significant differences between the groups (P = 0.227). Twenty-seven (27) of 100 (27.0%) eyes showed increased angular width of GCIPL defect. It was more frequent in the progression group than in the stable group (P = 0.043). Seventeen (17) of 27 (63.0%) eyes showed the away from the horizontal temporal raphe type progression and it was the most common change pattern of angular width of GCIPL defect. CONCLUSIONS: Increased angular width of GCIPL defect was the more prominent feature of change, and was more frequent in the progression group than in the stable group. Among the types of GCIPL defect classified, the away from the horizontal temporal raphe type was the most common.
Authors: Phuc V Le; Ou Tan; Vikas Chopra; Brian A Francis; Omar Ragab; Rohit Varma; David Huang Journal: Invest Ophthalmol Vis Sci Date: 2013-06-21 Impact factor: 4.799
Authors: D Huang; E A Swanson; C P Lin; J S Schuman; W G Stinson; W Chang; M R Hee; T Flotte; K Gregory; C A Puliafito Journal: Science Date: 1991-11-22 Impact factor: 47.728
Authors: Ko Eun Kim; Ki Ho Park; Beong Wook Yoo; Jin Wook Jeoung; Dong Myung Kim; Hee Chan Kim Journal: Invest Ophthalmol Vis Sci Date: 2014-05-06 Impact factor: 4.799