| Literature DB >> 1967721 |
M Lenzi1, G Ballardini, M Fusconi, F Cassani, L Selleri, U Volta, D Zauli, F B Bianchi.
Abstract
The prevalence of serum antibodies to hepatitis C virus (HCV) was assessed by an enzyme-linked immunosorbent assay in 46 patients seropositive for liver-kidney microsomal antibody (anti-LKM1), the marker of autoimmune hepatitis type 2. 43 had chronic hepatitis (with histological confirmation in 34) and 3 were seropositive for anti-LKM1 without clinical or biochemical evidence of liver damage. The overall prevalence of anti-HCV was 78.2% or 86.1% in patients with chronic hepatitis--a similar prevalence to that reported in patients with chronic non A, non B posttransfusion hepatitis. HCV infection may lead to altered expression of the hepatocellullar LKM1 target antigen, with loss of tolerance and appearance of anti-LKM1 in serum.Entities:
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Year: 1990 PMID： 1967721 DOI： 10.1016/0140-6736(90)90070-l
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321