Literature DB >> 1330460

Hepatitis C virus does not cause nonalcoholic steatohepatitis.

D W Rogers1, C H Lee, D C Pound, S Kumar, O W Cummings, L Lumeng.   

Abstract

The pathogenesis of nonalcoholic steatohepatitis (NASH) remains poorly understood. Since inflammation and fatty changes are associated with hepatitis C (HCV) infection, we have tested the role of HCV in the genesis of NASH. Five consecutive cases of classic NASH were tested by Abbott anti-c100-3 EIA and polymerase chain reaction (PCR) to detect HCV-RNA. All serum specimens were negative for anti-c100-3 (or anti-HCV EIA) and HCV PCR. Based on this study, we conclude that HCV does not play a causative or contributing role in the pathogenesis of NASH.

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Year:  1992        PMID： 1330460     DOI： 10.1007/bf01299852

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  19 in total

1.  Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis.

Authors:  J Bruix; J M Barrera; X Calvet; G Ercilla; J Costa; J M Sanchez-Tapias; M Ventura; M Vall; M Bruguera; C Bru
Journal:  Lancet       Date:  1989-10-28       Impact factor: 79.321

2.  The CAGE questionnaire: validation of a new alcoholism screening instrument.

Authors:  D Mayfield; G McLeod; P Hall
Journal:  Am J Psychiatry       Date:  1974-10       Impact factor: 18.112

3.  Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors.

Authors:  I R Wanless; J S Lentz
Journal:  Hepatology       Date:  1990-11       Impact factor: 17.425

Review 4.  Fatty liver disease in morbid obesity.

Authors:  D J Clain; J H Lefkowitch
Journal:  Gastroenterol Clin North Am       Date:  1987-06       Impact factor: 3.806

5.  Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5' untranslated region and poly(A) tails at the 3' end.

Authors:  J H Han; V Shyamala; K H Richman; M J Brauer; B Irvine; M S Urdea; P Tekamp-Olson; G Kuo; Q L Choo; M Houghton
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-01       Impact factor: 11.205

6.  Identification of hepatitis C viruses with a nonconserved sequence of the 5' untranslated region.

Authors:  C H Lee; C Cheng; J Wang; L Lumeng
Journal:  J Clin Microbiol       Date:  1992-06       Impact factor: 5.948

7.  An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis.

Authors:  G Kuo; Q L Choo; H J Alter; G L Gitnick; A G Redeker; R H Purcell; T Miyamura; J L Dienstag; M J Alter; C E Stevens
Journal:  Science       Date:  1989-04-21       Impact factor: 47.728

8.  Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease.

Authors:  J Ludwig; T R Viggiano; D B McGill; B J Oh
Journal:  Mayo Clin Proc       Date:  1980-07       Impact factor: 7.616

9.  Liver investigation in 149 asymptomatic patients with moderately elevated activities of serum aminotransferases.

Authors:  R Hultcrantz; H Glaumann; G Lindberg; L H Nilsson
Journal:  Scand J Gastroenterol       Date:  1986-01       Impact factor: 2.423

10.  Type 2 autoimmune hepatitis and hepatitis C virus infection.

Authors:  M Lenzi; G Ballardini; M Fusconi; F Cassani; L Selleri; U Volta; D Zauli; F B Bianchi
Journal:  Lancet       Date:  1990-02-03       Impact factor: 79.321
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  2 in total

Review 1.  Nonalcoholic fatty liver disease.

Authors:  Z M Younossi
Journal:  Curr Gastroenterol Rep       Date:  1999 Feb-Mar

2.  Nonalcoholic steatohepatitis. Clinicopathological comparison with alcoholic hepatitis in ambulatory and hospitalized patients.

Authors:  H C Pinto; A Baptista; M E Camilo; A Valente; A Saragoça; M C de Moura
Journal:  Dig Dis Sci       Date:  1996-01       Impact factor: 3.199
  2 in total

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