Literature DB >> 19669869

Experimental periodontitis induces a cAMP-dependent increase in amylase activity in parotid glands from male rats.

Valeria Miozza1, Enri Borda, Leonor Sterin-Borda, Lucila Busch.   

Abstract

It is known that subjects with periodontitis show enhanced amylase concentration in saliva. Our purpose was to analyze the release of amylase in parotid glands from rats with experimental periodontitis and controls. We present evidence that periodontitis induces an increase in resting amylase activity and release without changes in isoproterenol-induced amylase secretion. Changes in amylase were reverted by the inhibition of the adenylyl cyclase by SQ 22536, the cyclooxygenase type 1 by FR 122047 and by blocking the vasoactive intestinal peptide (VIP) receptor with VIP 6-28. Parotid glands from rats with periodontitis showed an increase in cAMP levels that was also reverted in the presence of SQ 22536, FR 122047 and VIP 6-28. We concluded that both PGE(2) and VIP are produced in parotid glands from rats with periodontitis and, by activating their own receptors in acinar cells, induce cAMP accumulation leading to an increase in amylase basal secretion.

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Year:  2009        PMID： 19669869     DOI： 10.1007/s10753-009-9142-2

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  27 in total

1.  Resting (basal) secretion of proteins is provided by the minor regulated and constitutive-like pathways and not granule exocytosis in parotid acinar cells.

Authors:  A Y Huang; A M Castle; B T Hinton; J D Castle
Journal:  J Biol Chem       Date:  2001-04-11       Impact factor: 5.157

Review 2.  VIP modulation of immune cell functions.

Authors:  M De la Fuente; M Delgado; R P Gomariz
Journal:  Adv Neuroimmunol       Date:  1996

3.  Alteration of cyclic nucleotides levels and oxidative stress in saliva of human subjects with periodontitis.

Authors:  Fereshteh Mashayekhi; Farzaneh Aghahoseini; Ali Rezaie; Mohammad J Zamani; Reza Khorasani; Mohammad Abdollahi
Journal:  J Contemp Dent Pract       Date:  2005-11-15

Review 4.  Intracellular transport and secretion of salivary proteins.

Authors:  D Castle; A Castle
Journal:  Crit Rev Oral Biol Med       Date:  1998

5.  Cyclic AMP and chloride-dependent regulation of the apical constitutive secretory pathway in colonic epithelial cells.

Authors:  T Jilling; K L Kirk
Journal:  J Biol Chem       Date:  1996-02-23       Impact factor: 5.157

6.  Gingival crevicular fluid interleukin-1beta, prostaglandin E2 and periodontal status in a community population.

Authors:  Y Zhong; G D Slade; J D Beck; S Offenbacher
Journal:  J Clin Periodontol       Date:  2007-04       Impact factor: 8.728

7.  Protein, albumin and cystatin concentrations in saliva of healthy subjects and of patients with gingivitis or periodontitis.

Authors:  Y M Henskens; U van der Velden; E C Veerman; A V Nieuw Amerongen
Journal:  J Periodontal Res       Date:  1993-01       Impact factor: 4.419

8.  Two regulated secretory pathways for newly synthesized parotid salivary proteins are distinguished by doses of secretagogues.

Authors:  J D Castle; A M Castle
Journal:  J Cell Sci       Date:  1996-10       Impact factor: 5.285

9.  Induction of tissue-specific proline-rich protein multigene families in rat and mouse parotid glands by isoproterenol. Unusual strain differences of proline-rich protein mRNAs.

Authors:  D K Ann; S Clements; E M Johnstone; D M Carlson
Journal:  J Biol Chem       Date:  1987-01-15       Impact factor: 5.157

Review 10.  Expression of vasoactive intestinal peptide in lymphocytes: a possible endogenous role in the regulation of the immune system.

Authors:  J Leceta; C Martínez; M Delgado; E Garrido; R P Gomariz
Journal:  Adv Neuroimmunol       Date:  1996
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  1 in total

1.  Estimation of levels of salivary mucin, amylase and total protein in gingivitis and chronic periodontitis patients.

Authors:  Swati Kejriwal; Rahul Bhandary; Biju Thomas; Suchetha Kumari
Journal:  J Clin Diagn Res       Date:  2014-10-20
  1 in total

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