Y Zhong1, G D Slade, J D Beck, S Offenbacher. 1. Department of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, NC 27599, USA.
Abstract
AIM: Interleukin-1 beta (IL-1beta) and prostaglandin E(2) (PGE(2)) are key inflammatory mediators involved in periodontal disease. The purposes of this molecular cross-sectional epidemiological study were to investigate relationships in a community sample between mean concentrations of IL-1beta and PGE(2) in gingival crevicular fluid (GCF) and (1) clinical periodontal signs and (2) risk factors of host inflammatory response and/or periodontal disease. MATERIAL AND METHODS: The sample comprised 6277 community-dwelling adults aged 52-74 years enrolled in the Atherosclerosis Risk in Communities (ARIC) study. IL-1beta and PGE(2) concentrations were measured using enzyme-linked immunosorbent assay. Person-level summary variables were computed for maximum pocket depth (MaxPD), maximum clinical attachment level (MaxCAL) and presence/absence of bleeding on probing (BOP). Mean GCF IL-1beta and PGE(2) concentrations were dependent variables in multiple linear regression models with periodontal measures and covariates as explanatory variables. RESULTS: Both GCF IL-1beta and PGE(2) were positively related to MaxPD and BOP in multiple regression models (p<0.01). Increased levels of IL-1beta and PGE(2) were associated with body mass index >or=30 kg/m(2). CONCLUSION: Higher levels of GCF IL-1beta and PGE(2) were significantly associated with clinical signs of periodontal disease and independently related to patient-based anthropomorphic measures, behaviours and exposures in community-dwelling adults.
AIM: Interleukin-1 beta (IL-1beta) and prostaglandin E(2) (PGE(2)) are key inflammatory mediators involved in periodontal disease. The purposes of this molecular cross-sectional epidemiological study were to investigate relationships in a community sample between mean concentrations of IL-1beta and PGE(2) in gingival crevicular fluid (GCF) and (1) clinical periodontal signs and (2) risk factors of host inflammatory response and/or periodontal disease. MATERIAL AND METHODS: The sample comprised 6277 community-dwelling adults aged 52-74 years enrolled in the Atherosclerosis Risk in Communities (ARIC) study. IL-1beta and PGE(2) concentrations were measured using enzyme-linked immunosorbent assay. Person-level summary variables were computed for maximum pocket depth (MaxPD), maximum clinical attachment level (MaxCAL) and presence/absence of bleeding on probing (BOP). Mean GCF IL-1beta and PGE(2) concentrations were dependent variables in multiple linear regression models with periodontal measures and covariates as explanatory variables. RESULTS: Both GCF IL-1beta and PGE(2) were positively related to MaxPD and BOP in multiple regression models (p<0.01). Increased levels of IL-1beta and PGE(2) were associated with body mass index >or=30 kg/m(2). CONCLUSION: Higher levels of GCF IL-1beta and PGE(2) were significantly associated with clinical signs of periodontal disease and independently related to patient-based anthropomorphic measures, behaviours and exposures in community-dwelling adults.
Authors: E S Ramos-Junior; A C Morandini; C L C Almeida-da-Silva; E J Franco; J Potempa; K A Nguyen; A C Oliveira; D S Zamboni; D M Ojcius; J Scharfstein; R Coutinho-Silva Journal: J Dent Res Date: 2015-07-07 Impact factor: 6.116
Authors: Steven Offenbacher; James D Beck; Kevin Moss; Luisito Mendoza; David W Paquette; David A Barrow; David J Couper; Dawn D Stewart; Karen L Falkner; Susan P Graham; Sara Grossi; John C Gunsolley; Theresa Madden; Gerardo Maupome; Maurizio Trevisan; Thomas E Van Dyke; Robert J Genco Journal: J Periodontol Date: 2009-02 Impact factor: 6.993
Authors: K Gawron; G Bereta; Z Nowakowska; K Lazarz-Bartyzel; M Lazarz; B Szmigielski; D Mizgalska; A Buda; J Koziel; Z Oruba; M Chomyszyn-Gajewska; J Potempa Journal: Mol Oral Microbiol Date: 2014-10-21 Impact factor: 3.563