INTRODUCTION: Genetic studies restricted to young adult ischemic stroke patients may help in excluding the potentially confounding variables encountered with advanced age; thus, allowing a more precise risk evaluation derived from the inherited mutations alone. Through meta-analysis, this study was conducted to determine the genetic risk contributed by each susceptibility gene polymorphism, particularly in adult early-onset ischemic stroke patients. MATERIALS AND METHODS: Electronic databases were searched for all the case-control studies relating to any candidate genes for ischemic stroke. The range of age was 18-50 years for cases. Fixed or random effects model was used depending on the heterogeneity between studies. RESULTS: Twenty-six studies were finally included in this meta-analysis; these studies focused on 7 candidate genes. A significant but modest association was identified for 2 polymorphisms, namely, methylenetetrahydrofolate reductase (MTHFR) C677T (OR = 1.44, 95% CI = 1.14-1.80) and apolipoprotein E (ApoE) epsilon2-4 (OR = 2.53, 95% CI = 1.71-3.73). Although the pooled analysis for platelet glycoprotein Ia (GPIa) C807T showed a positive association (OR = 1.50, 95% CI=1.10-2.05), the Egger's test indicated the existence of publication bias (t=5.27, P>|t|=0.034). CONCLUSIONS: Genetic abnormalities specific to homocysteine and lipid metabolism increase the risk for ischemic stroke at an early age. These data may offer important implications for future genetic association studies for stroke.
INTRODUCTION: Genetic studies restricted to young adult ischemic strokepatients may help in excluding the potentially confounding variables encountered with advanced age; thus, allowing a more precise risk evaluation derived from the inherited mutations alone. Through meta-analysis, this study was conducted to determine the genetic risk contributed by each susceptibility gene polymorphism, particularly in adult early-onset ischemic strokepatients. MATERIALS AND METHODS: Electronic databases were searched for all the case-control studies relating to any candidate genes for ischemic stroke. The range of age was 18-50 years for cases. Fixed or random effects model was used depending on the heterogeneity between studies. RESULTS: Twenty-six studies were finally included in this meta-analysis; these studies focused on 7 candidate genes. A significant but modest association was identified for 2 polymorphisms, namely, methylenetetrahydrofolate reductase (MTHFR) C677T (OR = 1.44, 95% CI = 1.14-1.80) and apolipoprotein E (ApoE) epsilon2-4 (OR = 2.53, 95% CI = 1.71-3.73). Although the pooled analysis for platelet glycoprotein Ia (GPIa) C807T showed a positive association (OR = 1.50, 95% CI=1.10-2.05), the Egger's test indicated the existence of publication bias (t=5.27, P>|t|=0.034). CONCLUSIONS:Genetic abnormalities specific to homocysteine and lipid metabolism increase the risk for ischemic stroke at an early age. These data may offer important implications for future genetic association studies for stroke.
Authors: Rogelio Palomino-Morales; Carlos Gonzalez-Juanatey; Tomas R Vazquez-Rodriguez; Luis Rodriguez; Jose A Miranda-Filloy; Benjamin Fernandez-Gutierrez; Javier Llorca; Javier Martin; Miguel A Gonzalez-Gay Journal: Arthritis Res Ther Date: 2010-04-26 Impact factor: 5.156
Authors: Yu-Ching Cheng; Tara M Stanne; Anne-Katrin Giese; Weang Kee Ho; Matthew Traylor; Philippe Amouyel; Elizabeth G Holliday; Rainer Malik; Huichun Xu; Steven J Kittner; John W Cole; Jeffrey R O'Connell; John Danesh; Asif Rasheed; Wei Zhao; Stefan Engelter; Caspar Grond-Ginsbach; Yoichiro Kamatani; Mark Lathrop; Didier Leys; Vincent Thijs; Tiina M Metso; Turgut Tatlisumak; Alessandro Pezzini; Eugenio A Parati; Bo Norrving; Steve Bevan; Peter M Rothwell; Cathie Sudlow; Agnieszka Slowik; Arne Lindgren; Matthew R Walters; Jim Jannes; Jess Shen; David Crosslin; Kimberly Doheny; Cathy C Laurie; Sandip M Kanse; Joshua C Bis; Myriam Fornage; Thomas H Mosley; Jemma C Hopewell; Konstantin Strauch; Martina Müller-Nurasyid; Christian Gieger; Melanie Waldenberger; Annette Peters; Christine Meisinger; M Arfan Ikram; W T Longstreth; James F Meschia; Sudha Seshadri; Pankaj Sharma; Bradford Worrall; Christina Jern; Christopher Levi; Martin Dichgans; Giorgio B Boncoraglio; Hugh S Markus; Stephanie Debette; Arndt Rolfs; Danish Saleheen; Braxton D Mitchell Journal: Stroke Date: 2016-01-05 Impact factor: 7.914