Literature DB >> 24132798

Synergistic effect of MTHFR C677T and F2 G20210A polymorphisms on ischemic stroke.

Thierry Paluku They-They1, Omar Battas, Sellama Nadifi.   

Abstract

The predisposition to stroke might involve interactive effects among variants in several genes. We tested this hypothesis by examining the influence of polymorphisms in methylenetetrahydrofolate reductase (MTHFR) (C677T) and prothrombin (F2) (G20210A) as risk factors for stroke in Morocco. The polymerase chain reaction-restriction fragment length polymorphism methods were used to analyze DNA from 91 stroke patients and 182 controls. Association between the two polymorphisms and the risk of stroke was estimated by four-level models for the analysis of genetic interaction. Neither the MTHFR 677TT nor the F2 20210GA genotype showed any significant association compared to the MTHFR CC and F2 GG genotypes, respectively. An interactive effect between the MTHFR 677TT and F2 20210GA polymorphisms showed an increased risk of stroke. The odds ratios, in univariate and multivariate analysis, for the combined polymorphisms were 4.99 (95% CI, 1.75-14.2, P = 0.001) and 5.29 (95% CI, 1.63-17.1, P = 0.005), respectively.

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Year:  2013        PMID： 24132798      PMCID： PMC5562548          DOI： 10.1007/s12264-013-1381-4

Source DB:  PubMed          Journal:  Neurosci Bull        ISSN： 1995-8218            Impact factor:   5.203


  36 in total

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2.  Planning genetic studies in human stroke: sample size estimates based on family history data.

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Journal:  Stroke       Date:  2002-03       Impact factor: 7.914

5.  Cumulative effect of predisposing genotypes and their interaction with modifiable factors on the risk of ischemic stroke in young adults.

Authors:  Alessandro Pezzini; Mario Grassi; Elisabetta Del Zotto; Silvana Archetti; Raffaella Spezi; Veronica Vergani; Deodato Assanelli; Luigi Caimi; Alessandro Padovani
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6.  Methylenehydrofolate reductase (C677T) polymorphism and large artery ischemic stroke subtypes.

Authors:  T P They-They; S Nadifi; M A Rafai; O Battas; I Slassi
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Review 7.  Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta-analysis of published studies.

Authors:  Robert J Kim; Richard C Becker
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9.  Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations.

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10.  C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of ischemic stroke in Polish subjects.

Authors:  I Goracy; L Cyryłowski; M Kaczmarczyk; A Fabian; D Koziarska; J Goracy; A Ciechanowicz
Journal:  J Appl Genet       Date:  2009       Impact factor: 3.240
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  5 in total

1.  MTHFR (C677T, A1298C), FV Leiden polymorphisms, and the prothrombin G20210A mutation in arterial ischemic stroke among young tunisian adults.

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Journal:  Metab Brain Dis       Date:  2021-01-05       Impact factor: 3.584

2.  Association of single nucleotide polymorphisms of MTHFR, TCN2, RNF213 with susceptibility to hypertension and blood pressure.

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3.  Genetic and lifestyle predictors of ischemic stroke severity and outcome.

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4.  Association of methylenetetrahydrofolate reductase gene (C677T) with the risk of hypertension in Morocco.

Authors:  Sanaa Nassereddine; Yaya Kassogue; Farah Korchi; Rachida Habbal; Sellama Nadifi
Journal:  BMC Res Notes       Date:  2015-12-12

5.  Ischemic stroke in Morocco: a systematic review.

Authors:  Ahmed Kharbach; Majdouline Obtel; Laila Lahlou; Jehanne Aasfara; Nour Mekaoui; Rachid Razine
Journal:  BMC Neurol       Date:  2019-12-30       Impact factor: 2.474
  5 in total

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