Literature DB >> 1965113

A study of the efficacy of the bradykinin antagonist, NPC 567, in rhinovirus infections in human volunteers.

P G Higgins1, G I Barrow, D A Tyrrell.   

Abstract

In a double-blind placebo controlled trial intranasal NPC 567, a bradykinin antagonist, failed to alleviate the symptoms of experimental rhinovirus colds. Indeed, there was evidence that the drug enhanced the symptoms although no irritant effect was detected on the uninfected nasal mucosa.

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Year:  1990        PMID： 1965113      PMCID： PMC7134172          DOI： 10.1016/0166-3542(90)90052-9

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  7 in total

1.  Kinins are generated in nasal secretions during natural rhinovirus colds.

Authors:  D Proud; R M Naclerio; J M Gwaltney; J O Hendley
Journal:  J Infect Dis       Date:  1990-01       Impact factor: 5.226

2.  Nasal provocation with bradykinin induces symptoms of rhinitis and a sore throat.

Authors:  D Proud; C J Reynolds; S Lacapra; A Kagey-Sobotka; L M Lichtenstein; R M Naclerio
Journal:  Am Rev Respir Dis       Date:  1988-03

3.  Kinins are generated during experimental rhinovirus colds.

Authors:  R M Naclerio; D Proud; L M Lichtenstein; A Kagey-Sobotka; J O Hendley; J Sorrentino; J M Gwaltney
Journal:  J Infect Dis       Date:  1988-01       Impact factor: 5.226

Review 4.  Bradykinin receptor antagonists.

Authors:  R M Burch; S G Farmer; L R Steranka
Journal:  Med Res Rev       Date:  1990 Apr-Jun       Impact factor: 12.944

5.  Suppression of colds in human volunteers challenged with rhinovirus by a new synthetic drug (R61837).

Authors:  W al-Nakib; P G Higgins; G I Barrow; D A Tyrrell; K Andries; G Vanden Bussche; N Taylor; P A Janssen
Journal:  Antimicrob Agents Chemother       Date:  1989-04       Impact factor: 5.191

6.  Mediators of immediate hypersensitivity in nasal secretions during natural colds and rhinovirus infection.

Authors:  P A Eggleston; J O Hendley; J M Gwaltney
Journal:  Acta Otolaryngol Suppl       Date:  1984

7.  Influence of atopy on the clinical manifestations of coronavirus infection in adult volunteers.

Authors:  K A Callow; D A Tyrrell; R J Shaw; P Fitzharris; A J Wardlaw; A B Kay
Journal:  Clin Allergy       Date:  1988-03
  7 in total
  10 in total

Review 1.  Problems and prospects of developing effective therapy for common cold viruses.

Authors:  S L Johnston
Journal:  Trends Microbiol       Date:  1997-02       Impact factor: 17.079

Review 2.  Nasal cytokines as mediators of illness during the common cold.

Authors:  William J Doyle; David P Skoner; Deborah Gentile
Journal:  Curr Allergy Asthma Rep       Date:  2005-05       Impact factor: 4.806

Review 3.  Viral rhinitis.

Authors:  D A Gentile; D P Skoner
Journal:  Curr Allergy Asthma Rep       Date:  2001-05       Impact factor: 4.806

4.  A study of the action of bradykinin and bradykinin analogues in the human nasal airway.

Authors:  C E Austin; J C Foreman
Journal:  J Physiol       Date:  1994-07-15       Impact factor: 5.182

Review 5.  Association of rhinovirus infections with asthma.

Authors:  J E Gern; W W Busse
Journal:  Clin Microbiol Rev       Date:  1999-01       Impact factor: 26.132

Review 6.  The kinin system in rhinitis and asthma.

Authors:  D Proud
Journal:  Clin Rev Allergy Immunol       Date:  1998       Impact factor: 8.667

Review 7.  Cromolyns: treatment for the common cold.

Authors:  S L Johnston
Journal:  Clin Exp Allergy       Date:  1996-09       Impact factor: 5.018

Review 8.  Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease.

Authors:  Alfred M Del Vecchio; Patrick J Branigan; Elliot S Barnathan; Susan K Flavin; Philip E Silkoff; Ronald B Turner
Journal:  Pulm Pharmacol Ther       Date:  2014-11-13       Impact factor: 3.410

Review 9.  Epidemiology, pathogenesis, and treatment of the common cold.

Authors:  R B Turner
Journal:  Ann Allergy Asthma Immunol       Date:  1997-06       Impact factor: 6.347

Review 10.  The common cold: current therapy and natural history.

Authors:  S L Spector
Journal:  J Allergy Clin Immunol       Date:  1995-05       Impact factor: 10.793
  10 in total

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