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Literature DB >> 19644775

Autoreactive B cells and epigenetics.

Yves Renaudineau¹, Soizic Garaud, Christelle Le Dantec, Ruby Alonso-Ramirez, Capucine Daridon, Pierre Youinou.

Abstract

Autoreactive B cells are central in the pathogenesis of autoimmune diseases (AID) not only by producing autoantibodies but also by secreting cytokines and by presenting autoantigens. Changes in DNA methylation, histone modifications, and miRNA expression, the hallmarks of epigenetic failure, characterize B cells isolated from patients with AID, highlighting the contribution of epigenetic processes to autoreactivity. Additional evidence of epigenetic involvement in the development of B cell autoreactivity comes from in vivo and in vitro studies using DNA demethylating agents as accelerating factors or histone deacetylase inhibitors as repressing factors. As a result, a better understanding of the altered epigenetic processes in AID and in particular in B cells opens perspectives for the development of new therapeutics.

Entities: Disease Species

Mesh：

Substances：

Year: 2010 PMID： 19644775 DOI： 10.1007/s12016-009-8174-6

Source DB: PubMed Journal: Clin Rev Allergy Immunol ISSN： 1080-0549 Impact factor: 8.667

87 in total

1. An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes.

Authors: Yves Renaudineau; Sophie Hillion; Alain Saraux; Rizgar A Mageed; Pierre Youinou
Journal: Blood Date: 2005-07-05 Impact factor: 22.113

2. Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds.

Authors: Y Qian; C Santiago; M Borrero; T F Tedder; S H Clarke
Journal: J Immunol Date: 2001-02-15 Impact factor: 5.422

3. Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis.

Authors: B Richardson; L Scheinbart; J Strahler; L Gross; S Hanash; M Johnson
Journal: Arthritis Rheum Date: 1990-11

4. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

Authors: Geoffrey Hom; Robert R Graham; Barmak Modrek; Kimberly E Taylor; Ward Ortmann; Sophie Garnier; Annette T Lee; Sharon A Chung; Ricardo C Ferreira; P V Krishna Pant; Dennis G Ballinger; Roman Kosoy; F Yesim Demirci; M Ilyas Kamboh; Amy H Kao; Chao Tian; Iva Gunnarsson; Anders A Bengtsson; Solbritt Rantapää-Dahlqvist; Michelle Petri; Susan Manzi; Michael F Seldin; Lars Rönnblom; Ann-Christine Syvänen; Lindsey A Criswell; Peter K Gregersen; Timothy W Behrens
Journal: N Engl J Med Date: 2008-01-20 Impact factor: 91.245

5. IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation.

Authors: Soizic Garaud; Christelle Le Dantec; Sandrine Jousse-Joulin; Catherine Hanrotel-Saliou; Alain Saraux; Rizgar A Mageed; Pierre Youinou; Yves Renaudineau
Journal: J Immunol Date: 2009-05-01 Impact factor: 5.422

6. Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation.

Authors: David R Fernandez; Tiffany Telarico; Eduardo Bonilla; Qing Li; Sanjay Banerjee; Frank A Middleton; Paul E Phillips; Mary K Crow; Stefanie Oess; Werner Muller-Esterl; Andras Perl
Journal: J Immunol Date: 2009-02-15 Impact factor: 5.422

7. Abnormal histone modification patterns in lupus CD4+ T cells.

Authors: Nan Hu; Xiangning Qiu; Yongqi Luo; Jun Yuan; Yaping Li; Wenzhi Lei; Guiying Zhang; Ying Zhou; Yuwen Su; Qianjin Lu
Journal: J Rheumatol Date: 2008-04-01 Impact factor: 4.666

8. MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins.

Authors: Yuanjia Tang; Xiaobing Luo; Huijuan Cui; Xuming Ni; Min Yuan; Yanzhi Guo; Xinfang Huang; Haibo Zhou; Niek de Vries; Paul Peter Tak; Shunle Chen; Nan Shen
Journal: Arthritis Rheum Date: 2009-04

Autoreactive B cells and epigenetics.

1. An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes.

2. Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds.

3. Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis.

4. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

5. IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation.

6. Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation.

7. Abnormal histone modification patterns in lupus CD4+ T cells.

8. MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins.

9. Defective B-cell-negative selection and terminal differentiation in the ICF syndrome.

10. PADI4 polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis.

Review 1. The therapeutic potential of epigenetics in autoimmune diseases.

2. Cutting-edge issues in organ-specific autoimmunity.

Review 3. The long-term marriage between autoimmunity and internal medicine: a homage to Manuel Carlos Dias.

4. DNA methylation changes on immune cells in Systemic Lupus Erythematosus.

5. Mechanisms and pathophysiology of autoimmune disease.

Review 6. Application of genetic/genomic approaches to allergic disorders.

7. CD20⁺CD22⁺ADAM28⁺ B Cells in Tertiary Lymphoid Structures Promote Immunotherapy Response.

8. The role of epigenetic mechanisms and processes in autoimmune disorders.

Review 9. Epigenetic regulation in B-cell maturation and its dysregulation in autoimmunity.