Literature DB >> 2242063

Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis.

B Richardson1, L Scheinbart, J Strahler, L Gross, S Hanash, M Johnson.   

Abstract

Procainamide and hydralazine inhibit T cell DNA methylation and induce autoreactivity in cloned CD4+ T cells. These drugs also induce an autoimmune syndrome, suggesting a possible relationship between DNA hypomethylation, T cell autoreactivity, and certain autoimmune diseases. To test this relationship, DNA methylation was studied in T cells from patients with rheumatoid arthritis and patients with systemic lupus erythematosus, and was found to be impaired. These results support a relationship between DNA hypomethylation and some forms of autoimmune disease.

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Year:  1990        PMID： 2242063     DOI： 10.1002/art.1780331109

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  171 in total

1.  Analysis of human peripheral blood T cells and single-cell-derived T cell clones uncovers extensive clonal CpG island methylation heterogeneity throughout the genome.

Authors:  X Zhu; C Deng; R Kuick; R Yung; B Lamb; J V Neel; B Richardson; S Hanash
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

Review 2.  Nucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus.

Authors:  P Lenert
Journal:  Clin Exp Immunol       Date:  2010-05-07       Impact factor: 4.330

3.  IVIg attenuates TLR-9 activation in B cells from SLE patients.

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Journal:  J Clin Immunol       Date:  2010-10-05       Impact factor: 8.317

Review 4.  The therapeutic potential of epigenetics in autoimmune diseases.

Authors:  Maria De Santis; Carlo Selmi
Journal:  Clin Rev Allergy Immunol       Date:  2012-02       Impact factor: 8.667

Review 5.  Epigenetic regulation in alcoholic liver disease.

Authors:  Pranoti Mandrekar
Journal:  World J Gastroenterol       Date:  2011-05-28       Impact factor: 5.742

6.  Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus.

Authors:  Faith M Strickland; Anura Hewagama; Qianjian Lu; Ailing Wu; Robert Hinderer; Ryan Webb; Kent Johnson; Amr H Sawalha; Colin Delaney; Raymond Yung; Bruce C Richardson
Journal:  J Autoimmun       Date:  2011-12-03       Impact factor: 7.094

7.  Human leptin tissue distribution, but not weight loss-dependent change in expression, is associated with methylation of its promoter.

Authors:  Matilde Marchi; Simonetta Lisi; Michele Curcio; Serena Barbuti; Paolo Piaggi; Giovanni Ceccarini; Monica Nannipieri; Marco Anselmino; Claudio Di Salvo; Paolo Vitti; Aldo Pinchera; Ferruccio Santini; Margherita Maffei
Journal:  Epigenetics       Date:  2011-10-01       Impact factor: 4.528

Review 8.  The epigenetics of autoimmunity.

Authors:  Francesca Meda; Marco Folci; Andrea Baccarelli; Carlo Selmi
Journal:  Cell Mol Immunol       Date:  2011-01-31       Impact factor: 11.530

9.  Genetic factors predisposing to systemic lupus erythematosus and lupus nephritis.

Authors:  Paula S Ramos; Elisabeth E Brown; Robert P Kimberly; Carl D Langefeld
Journal:  Semin Nephrol       Date:  2010-03       Impact factor: 5.299

10.  Sex-specific differences in the relationship between genetic susceptibility, T cell DNA demethylation and lupus flare severity.

Authors:  Amr H Sawalha; Lu Wang; Ajay Nadig; Emily C Somers; W Joseph McCune; Travis Hughes; Joan T Merrill; R Hal Scofield; Faith M Strickland; Bruce Richardson
Journal:  J Autoimmun       Date:  2012-02-03       Impact factor: 7.094
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