Literature DB >> 32019373

DNA methylation changes on immune cells in Systemic Lupus Erythematosus.

Carolina Hurtado1, Liliana Yazmín Acevedo Sáenz2, Elsa María Vásquez Trespalacios3, Rodrigo Urrego4, Scott Jenks5, Iñaki Sanz5, Gloria Vásquez6.   

Abstract

DNA methylation as a process that regulates gene expression is crucial in immune cells biology. Global and gene specific methylation changes have been described in autoimmunity, especially in Systemic Lupus Erythematosus. These changes not only contribute to the understanding of the disease, but also some have been proposed as diagnostic or disease activity biomarkers. The present review compiles the most recent discoveries on this field on each type of immune cells, including specific changes in signalling pathways, genes of interest and its possible applications on diagnosis or treatment.

Entities:  

Keywords:  DNA methylation; Systemic Lupus Erythematosus; autoimmunity

Year:  2020        PMID： 32019373      PMCID： PMC8063264          DOI： 10.1080/08916934.2020.1722108

Source DB:  PubMed          Journal:  Autoimmunity        ISSN： 0891-6934            Impact factor:   2.815


  71 in total

1.  Gender differences of B cell signature related to estrogen-induced IFI44L/BAFF in systemic lupus erythematosus.

Authors:  Hongye Fan; Guangfeng Zhao; Deshan Ren; Fei Liu; Guanjun Dong; Yayi Hou
Journal:  Immunol Lett       Date:  2016-12-05       Impact factor: 3.685

Review 2.  T cells and IL-17 in lupus nephritis.

Authors:  Tomohiro Koga; Kunihiro Ichinose; George C Tsokos
Journal:  Clin Immunol       Date:  2016-04-21       Impact factor: 3.969

3.  MicroRNA-29b contributes to DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus by indirectly targeting DNA methyltransferase 1.

Authors:  Haihong Qin; Xiaohua Zhu; Jun Liang; Jinfeng Wu; Yongsheng Yang; Shangshang Wang; Weimin Shi; Jinhua Xu
Journal:  J Dermatol Sci       Date:  2012-10-24       Impact factor: 4.563

4.  Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells.

Authors:  Ming Zhao; Yimin Sun; Fei Gao; Xiaoyan Wu; Jinling Tang; Heng Yin; Yongqi Luo; Bruce Richardson; Qianjin Lu
Journal:  J Autoimmun       Date:  2010-03-11       Impact factor: 7.094

5.  MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1.

Authors:  Sha Zhao; Yu Wang; Yunsheng Liang; Ming Zhao; Hai Long; Shu Ding; Heng Yin; Qianjin Lu
Journal:  Arthritis Rheum       Date:  2011-05

6.  17β-oestradiol enhances global DNA hypomethylation in CD4-positive T cells from female patients with lupus, through overexpression of oestrogen receptor-α-mediated downregulation of DNMT1.

Authors:  Z Wu; Y Sun; X Mei; C Zhang; W Pan; W Shi
Journal:  Clin Exp Dermatol       Date:  2014-06       Impact factor: 3.470

7.  Increased Set1 binding at the promoter induces aberrant epigenetic alterations and up-regulates cyclic adenosine 5'-monophosphate response element modulator alpha in systemic lupus erythematosus.

Authors:  Qing Zhang; Shu Ding; Huilin Zhang; Hai Long; Haijing Wu; Ming Zhao; Vera Chan; Chak-Sing Lau; Qianjin Lu
Journal:  Clin Epigenetics       Date:  2016-11-24       Impact factor: 6.551

8.  IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation.

Authors:  Ming Zhao; Yixin Tan; Qiao Peng; Cancan Huang; Yu Guo; Gongping Liang; Bochen Zhu; Yi Huang; Aiyun Liu; Zijun Wang; Mengying Li; Xiaofei Gao; Ruifang Wu; Haijing Wu; Hai Long; Qianjin Lu
Journal:  Nat Commun       Date:  2018-02-08       Impact factor: 14.919

9.  Epigenetic programming underpins B cell dysfunction in human SLE.

Authors:  Christopher D Scharer; Emily L Blalock; Tian Mi; Benjamin G Barwick; Scott A Jenks; Tsuneo Deguchi; Kevin S Cashman; Bridget E Neary; Dillon G Patterson; Sakeenah L Hicks; Arezou Khosroshahi; F Eun-Hyung Lee; Chungwen Wei; Iñaki Sanz; Jeremy M Boss
Journal:  Nat Immunol       Date:  2019-07-01       Impact factor: 25.606

10.  Oxidative stress, T cell DNA methylation, and lupus.

Authors:  YePeng Li; Gabriela Gorelik; Faith M Strickland; Bruce C Richardson
Journal:  Arthritis Rheumatol       Date:  2014-06       Impact factor: 10.995
View more
  3 in total

Review 1.  Sex bias in systemic lupus erythematosus: a molecular insight.

Authors:  Moumita Bose; Caroline Jefferies
Journal:  Immunometabolism (Cobham)       Date:  2022-07-29

2.  Altered B cell phenotype and CD27+ memory B cells are associated with clinical features and environmental exposure in Colombian systemic lupus erythematosus patients.

Authors:  Carolina Hurtado; Diego Fernando Rojas-Gualdrón; Rodrigo Urrego; Kevin Cashman; Elsa María Vásquez-Trespalacios; Juan Camilo Díaz-Coronado; Mauricio Rojas; Scott Jenks; Gloria Vásquez; Ignacio Sanz
Journal:  Front Med (Lausanne)       Date:  2022-09-06

3.  Methyl donor micronutrients, CD40-ligand methylation and disease activity in systemic lupus erythematosus: A cross-sectional association study.

Authors:  Stefan Vordenbäumen; Alexander Sokolowski; Anna Rosenbaum; Claudia Gebhard; Johanna Raithel; Christina Düsing; Gamal Chehab; Jutta G Richter; Ralph Brinks; Michael Rehli; Matthias Schneider
Journal:  Lupus       Date:  2021-07-20       Impact factor: 2.911
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.