| Literature DB >> 19644516 |
Soleiman Helaly1, Kathrin Schneider, Jonny Nachtigall, Sabaratnam Vikineswary, Geok Yuan Annie Tan, Heidi Zinecker, Johannes F Imhoff, Roderich D Süssmuth, Hans-Peter Fiedler.
Abstract
Gombapyrones A-D, new members of the alpha-pyrone family of secondary metabolites, were produced by Streptomyces griseoruber Acta 3662, which was isolated from bamboo tree rhizosphere. The strain was characterized by its morphological and chemotaxonomical features and by 16S rDNA sequencing as S. griseobuber. The gombapyrone structures were determined by mass spectrometry and by NMR experiments, and were found to have an inhibitory activity against protein tyrosine phosphatase 1B and glycogen synthase kinase 3beta.Entities:
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Year: 2009 PMID： 19644516 DOI： 10.1038/ja.2009.70
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649