Literature DB >> 19636920

Backbone NMR resonance assignment of the Abelson kinase domain in complex with imatinib.

Navratna Vajpai1, André Strauss, Gabriele Fendrich, Sandra W Cowan-Jacob, Paul W Manley, Wolfgang Jahnke, Stephan Grzesiek.   

Abstract

Imatinib (Glivec or Gleevec) potently inhibits the tyrosine kinase activity of BCR-ABL, a constitutively activated kinase, which causes chronic myelogenous leukemia (CML). Here we report the first almost complete backbone assignment of c-ABL kinase domain in complex with imatinib.

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Year:  2008        PMID： 19636920     DOI： 10.1007/s12104-008-9079-7

Source DB:  PubMed          Journal:  Biomol NMR Assign        ISSN： 1874-270X            Impact factor:   0.746


  10 in total

1.  Isotope labeling in insect cells.

Authors:  Krishna Saxena; Arpana Dutta; Judith Klein-Seetharaman; Harald Schwalbe
Journal:  Methods Mol Biol       Date:  2012

2.  A simple protocol for amino acid type selective isotope labeling in insect cells with improved yields and high reproducibility.

Authors:  Alvar D Gossert; Alexandra Hinniger; Sascha Gutmann; Wolfgang Jahnke; André Strauss; César Fernández
Journal:  J Biomol NMR       Date:  2011-10-02       Impact factor: 2.835

3.  Abl kinase constructs expressed in bacteria: facilitation of structural and functional studies including segmental labeling by expressed protein ligation.

Authors:  Rong Xu; Dongsheng Liu; David Cowburn
Journal:  Mol Biosyst       Date:  2012-05-16

4.  Affordable uniform isotope labeling with (2)H, (13)C and (15)N in insect cells.

Authors:  Agnieszka Sitarska; Lukasz Skora; Julia Klopp; Susan Roest; César Fernández; Binesh Shrestha; Alvar D Gossert
Journal:  J Biomol NMR       Date:  2015-05-01       Impact factor: 2.835

5.  Structural basis of p38α regulation by hematopoietic tyrosine phosphatase.

Authors:  Dana M Francis; Bartosz Różycki; Dorothy Koveal; Gerhard Hummer; Rebecca Page; Wolfgang Peti
Journal:  Nat Chem Biol       Date:  2011-11-06       Impact factor: 15.040

Review 6.  Production of isotope-labeled proteins in insect cells for NMR.

Authors:  Bastian Franke; Christian Opitz; Shin Isogai; Anne Grahl; Leonildo Delgado; Alvar D Gossert; Stephan Grzesiek
Journal:  J Biomol NMR       Date:  2018-04-23       Impact factor: 2.835

7.  An economic approach to efficient isotope labeling in insect cells using homemade 15N-, 13C- and 2H-labeled yeast extracts.

Authors:  Christian Opitz; Shin Isogai; Stephan Grzesiek
Journal:  J Biomol NMR       Date:  2015-06-13       Impact factor: 2.835

8.  NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors.

Authors:  Lukasz Skora; Jürgen Mestan; Doriano Fabbro; Wolfgang Jahnke; Stephan Grzesiek
Journal:  Proc Natl Acad Sci U S A       Date:  2013-11-04       Impact factor: 11.205

9.  An extended combinatorial 15N, 13Cα, and 13C' labeling approach to protein backbone resonance assignment.

Authors:  Frank Löhr; Franz Tumulka; Christoph Bock; Rupert Abele; Volker Dötsch
Journal:  J Biomol NMR       Date:  2015-05-08       Impact factor: 2.835

10.  Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase.

Authors:  Tobias Klein; Navratna Vajpai; Jonathan J Phillips; Gareth Davies; Geoffrey A Holdgate; Chris Phillips; Julie A Tucker; Richard A Norman; Andrew D Scott; Daniel R Higazi; David Lowe; Gary S Thompson; Alexander L Breeze
Journal:  Nat Commun       Date:  2015-07-23       Impact factor: 14.919
  10 in total

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