Owing to increased needs for positron emission tomography (PET), high demands for a wide variety of radiolabeled compounds will have to be met by exploiting novel radiochemistry and engineering technologies to improve the production and development of PET probes. The application of microfluidic reactors to perform radiosyntheses is currently attracting a great deal of interest because of their potential to deliver many advantages over conventional labeling systems. Microfluidics-based radiochemistry can lead to the use of smaller quantities of precursors, accelerated reaction rates, and easier purification processes with greater yield and higher specific activity of desired probes. Several proof-of-principle examples along with the basics of device architecture and operation and the potential limitations of each design are discussed. Along with the concept of radioisotope distribution from centralized cyclotron facilities to individual imaging centers and laboratories ("decentralized model"), an easy-to-use, stand-alone, flexible, fully automated, radiochemical microfluidic platform can provide simpler and more cost-effective procedures for molecular imaging using PET.
Owing to increased needs for positron emission tomography (PET), high demaical">nds for a wide varietn class="Chemical">y of radiolabeled compounds will have to be met by exploiting novel radiochemistry and engineering technologies to improve the production and development of PET probes. The application of microfluidic reactors to perform radiosyntheses is currently attracting a great deal of interest because of their potential to deliver many advantages over conventional labeling systems. Microfluidics-based radiochemistry can lead to the use of smaller quantities of precursors, accelerated reaction rates, and easier purification processes with greater yield and higher specific activity of desired probes. Several proof-of-principle examples along with the basics of device architecture and operation and the potential limitations of each design are discussed. Along with the concept of radioisotope distribution from centralized cyclotron facilities to individual imaging centers and laboratories ("decentralized model"), an easy-to-use, stand-alone, flexible, fully automated, radiochemical microfluidic platform can provide simpler and more cost-effective procedures for molecular imaging using PET.
Authors: Lutz W Kracht; Hrvoje Miletic; Susanne Busch; Andreas H Jacobs; Jurgen Voges; Moritz Hoevels; Johannes C Klein; Karl Herholz; Wolf-D Heiss Journal: Clin Cancer Res Date: 2004-11-01 Impact factor: 12.531
Authors: Nicolaas I Bohnen; Hiroto Kuwabara; Gregory M Constantine; Chester A Mathis; Robert Y Moore Journal: Neurosci Lett Date: 2007-08-06 Impact factor: 3.046
Authors: Vanessa L Cropley; Robert B Innis; Pradeep J Nathan; Amira K Brown; Janet L Sangare; Alicja Lerner; Yong Hoon Ryu; Kelly E Sprague; Victor W Pike; Masahiro Fujita Journal: Synapse Date: 2008-06 Impact factor: 2.562
Authors: Emmanuelle Briard; Sami S Zoghbi; Fabrice G Siméon; Masao Imaizumi; Jonathan P Gourley; H Umesha Shetty; Shuiyu Lu; Masahiro Fujita; Robert B Innis; Victor W Pike Journal: J Med Chem Date: 2009-02-12 Impact factor: 7.446
Authors: Christopher Frank; Georg Winter; Fredrik Rensei; Victor Samper; Allen F Brooks; Brian G Hockley; Bradford D Henderson; Christian Rensch; Peter J H Scott Journal: EJNMMI Radiopharm Chem Date: 2019-09-18