Literature DB >> 19631423

Synthesis, antimicrobial and antioxidant activities of substituted pyrazoles, isoxazoles, pyrimidine and thioxopyrimidine derivatives.

A Padmaja1, T Payani, G Dinneswara Reddy, V Padmavathi.   

Abstract

A new class of heterocycles, substituted pyrazoles, isoxazoles, pyrimidines, thioxopyrimidines were prepared from Michael adducts, 2-(1,2-diaroylethyl)malononitrile and 2-(1,2-diarylsulfonylethyl)malononitrile by cyclocondensation with appropriate nucleophiles. The lead compounds were screened for the antimicrobial and antioxidant activities.

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Year:  2009        PMID： 19631423     DOI： 10.1016/j.ejmech.2009.06.024

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  13 in total

Review 1.  Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review.

Authors:  Khalid Karrouchi; Smaail Radi; Youssef Ramli; Jamal Taoufik; Yahia N Mabkhot; Faiz A Al-Aizari; M'hammed Ansar
Journal:  Molecules       Date:  2018-01-12       Impact factor: 4.411

2.  Reactivity of pyrazole derivatives with halomethanes: A DFT theoretical study.

Authors:  Monia Chebbi; Youssef Arfaoui
Journal:  J Mol Model       Date:  2018-07-09       Impact factor: 1.810

3.  Organocatalytic asymmetric addition of malonates to unsaturated 1,4-diketones.

Authors:  Sergei Zari; Tiiu Kailas; Marina Kudrjashova; Mario Oeren; Ivar Järving; Toomas Tamm; Margus Lopp; Tõnis Kanger
Journal:  Beilstein J Org Chem       Date:  2012-09-04       Impact factor: 2.883

Review 4.  Significance and biological importance of pyrimidine in the microbial world.

Authors:  Vinita Sharma; Nitin Chitranshi; Ajay Kumar Agarwal
Journal:  Int J Med Chem       Date:  2014-03-23

5.  Experimental and theoretical study on structure-tautomerism among edaravone, isoxazolone, and their heterocycles derivatives as antioxidants.

Authors:  Auriekson N Queiroz; Camila C Martins; Kelton L B Santos; Ederson S Carvalho; Alex O Owiti; Karen R M Oliveira; Anderson M Herculano; Albérico B F da Silva; Rosivaldo S Borges
Journal:  Saudi Pharm J       Date:  2020-06-12       Impact factor: 4.330

6.  4-(Pyrimidin-2-yl)piperazin-1-ium (E)-3-carb-oxy-prop-2-enoate.

Authors:  Thammarse S Yamuna; Manpreet Kaur; Jerry P Jasinski; H S Yathirajan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-05-24

7.  Crystal structure of 3-[4-(pyrimidin-2-yl)piperazin-1-ium-1-yl]butano-ate.

Authors:  Thammarse S Yamuna; Jerry P Jasinski; Manpreet Kaur; Brian J Anderson; H S Yathirajan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-08-30

8.  Crystal structures of 4-(pyrimidin-2-yl)piperazin-1-ium chloride and 4-(pyrimidin-2-yl)piperazin-1-ium nitrate.

Authors:  Thammarse S Yamuna; Jerry P Jasinski; Manpreet Kaur; Brian J Anderson; H S Yathirajan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-09-13

9.  The biological activity of new thieno[2,3-c]pyrazole compounds as anti-oxidants against toxicity of 4-nonylphenol in Clarias gariepinus.

Authors:  Alaa El-Din H Sayed; Remon M Zaki; Adel M Kamal El-Dean; Abdullah Y Abdulrazzaq
Journal:  Toxicol Rep       Date:  2015-10-21

10.  Synthesis of Some Benzofuran Derivatives Containing Pyrimidine Moiety as Potent Antimicrobial Agents.

Authors:  Talavara Venkatesh; Yadav Dasharathrao Bodke; Muthipeedika Nibin Joy; Bhadrapura Lakkappa Dhananjaya; Sivaramakrishnan Venkataraman
Journal:  Iran J Pharm Res       Date:  2018       Impact factor: 1.696
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