OBJECTIVES: To test whether renal cell carcinoma (RCC) histologic subtypes (HSs) affect cancer-specific mortality after nephron-sparing surgery (NSS). HSs are considered of prognostic value in RCC. For example, the papillary HS might confer a worse prognosis, and, at some centers, only radical nephrectomy is performed for the papillary HS. METHODS: We used univariate and multivariate Cox regression models to study patients with Stage T1N0M0 RCC treated with NSS (n = 1205) from 1988 to 2004. The data were taken from 9 Surveillance, Epidemiology, and End Results registries. RESULTS: At 36 months after NSS, the cancer-specific mortality rate was 97.8%, 100%, and 97.4% for a clear cell, chromophobe, and papillary RCC HS, respectively. On univariate and multivariate analyses, no statistically significant differences were recorded with regard to the HS. CONCLUSIONS: Despite the suggested more aggressive phenotype of the papillary HS, we found no difference among the papillary, chromophobe, and clear cell variants. Thus, the diagnosis of one HS vs another HS should not deter from the use of NSS when cancer-specific mortality is considered as an endpoint.
OBJECTIVES: To test whether renal cell carcinoma (RCC) histologic subtypes (HSs) affect cancer-specific mortality after nephron-sparing surgery (NSS). HSs are considered of prognostic value in RCC. For example, the papillary HS might confer a worse prognosis, and, at some centers, only radical nephrectomy is performed for the papillary HS. METHODS: We used univariate and multivariate Cox regression models to study patients with Stage T1N0M0 RCC treated with NSS (n = 1205) from 1988 to 2004. The data were taken from 9 Surveillance, Epidemiology, and End Results registries. RESULTS: At 36 months after NSS, the cancer-specific mortality rate was 97.8%, 100%, and 97.4% for a clear cell, chromophobe, and papillary RCC HS, respectively. On univariate and multivariate analyses, no statistically significant differences were recorded with regard to the HS. CONCLUSIONS: Despite the suggested more aggressive phenotype of the papillary HS, we found no difference among the papillary, chromophobe, and clear cell variants. Thus, the diagnosis of one HS vs another HS should not deter from the use of NSS when cancer-specific mortality is considered as an endpoint.
Authors: M May; R Zigeuner; A Aziz; L Cindolo; C Gilfrich; L Schips; O De Cobelli; B Rocco; C De Nunzio; A Tubaro; I Coman; B Feciche; M Truss; B Hoschke; O Dalpiaz; A Stoltze; F Fenske; H-M Fritsche; T Chromecki; S Lebentrau; R S Figenshau; K Madison; M Sánchez-Chapado; M Del Carmen Santiago Martin; L Salzano; G Lotrecchiano; S Joniau; R Waidelich; C G Stief; S Brookman-May Journal: Urologe A Date: 2014-02 Impact factor: 0.639
Authors: Daniel P Nguyen; Emily A Vertosick; Renato B Corradi; Antoni Vilaseca; Nicole E Benfante; Karim A Touijer; Daniel D Sjoberg; Paul Russo Journal: Urol Oncol Date: 2016-03-02 Impact factor: 3.498
Authors: Pierre Bigot; Jean-Christophe Bernhard; Inderbir S Gill; Nam Son Vuong; Grégory Verhoest; Vincent Flamand; Boris Reix; Evren Suer; Ilker Gökce; Jean Baptiste Beauval; François Xavier Nouhaud; Masatoshi Eto; Eduard Baco; Toru Matsugasumi; Yvonne Chowaniec; Jérôme Rigaud; Claire Lenormand; Christian Pfister; Jean François Hetet; Guillaume Ploussard; Morgan Roupret; Priscilla Léon; Adnan El Bakri; Stéphane Larré; Xavier Tillou; Arnaud Doerfler; Aurélien Descazeaud; Nicolas Koutlidis; Alexandre Schneider; Philippe Sebe; Alexandre Ingels; Abdel Rahmène Azzouzi; Michel Soulié; Arnaud Méjean; Karim Bensalah; Jean-Jacques Patard Journal: World J Urol Date: 2015-07-07 Impact factor: 4.226
Authors: Pierre Bigot; Jean-Christophe Bernhard; Vincent Flamand; Inderbir Gill; Grégory Verhoest; Jean Baptiste Beauval; François Xavier Nouhaud; Evren Suer; Guillaume Ploussard; Jean François Hetet; Jérôme Rigaud; Eduard Baco; Stéphane Larré; Philippe Sebe; Nicolas Koutlidis; Aurélien Descazeaud; Masatoshi Eto; Arnaud Doerfler; Morgan Roupret; Nam Son Vuong; Boris Reix; Toru Matsugasumi; Adnan El Bakri; Laurence Albiges; Michel Soulié; Jean-Jacques Patard; Arnaud Méjean; Karim Bensalah Journal: Urol Oncol Date: 2016-09-28 Impact factor: 3.498