BACKGROUND AND AIM: Non-ST-segment elevation myocardial infarction (NSTEMI) cannot be easily detected in the emergency room. We evaluate a method to detect NSTEMI using 64-channel magnetocardiography (MCG). METHODS: MCG recordings were made in 20 NSTEMI patients (aged 59.7+/-12.4 years), 15 young (aged 26.8+/-3.4 years), and 13 age-matched control subjects (aged 57.3+/-3.6). We evaluated three approaches to analysis, including 1) determination when individual subjects' MCG results fell outside normal ranges for ten MCG parameters, 2) the magnetic field map at the T-wave peak (T-MFM), and 3) a pair of spatiotemporal activation graphs (STAGs) showing two projections of electrical excitation during repolarization. RESULTS: Significant differences were found between normal controls and patients for all MCG parameters. None of the healthy controls had more than four MCG abnormal parameters, whereas 19 NSTEMI patients (95%) were abnormal in more than four parameters. STAGs and T-MFM also showed clear differences between healthy controls and NSTEMI patients. CONCLUSIONS: These results suggest that the MCG is sensitive to changes in the cardiac electrical pathway after myocardial infarction as described by these graphs and parameters, and therefore MCG may be a useful tool to detect severe ischemic patients.
BACKGROUND AND AIM: Non-ST-segment elevation myocardial infarction (NSTEMI) cannot be easily detected in the emergency room. We evaluate a method to detect NSTEMI using 64-channel magnetocardiography (MCG). METHODS: MCG recordings were made in 20 NSTEMI patients (aged 59.7+/-12.4 years), 15 young (aged 26.8+/-3.4 years), and 13 age-matched control subjects (aged 57.3+/-3.6). We evaluated three approaches to analysis, including 1) determination when individual subjects' MCG results fell outside normal ranges for ten MCG parameters, 2) the magnetic field map at the T-wave peak (T-MFM), and 3) a pair of spatiotemporal activation graphs (STAGs) showing two projections of electrical excitation during repolarization. RESULTS: Significant differences were found between normal controls and patients for all MCG parameters. None of the healthy controls had more than four MCG abnormal parameters, whereas 19 NSTEMI patients (95%) were abnormal in more than four parameters. STAGs and T-MFM also showed clear differences between healthy controls and NSTEMI patients. CONCLUSIONS: These results suggest that the MCG is sensitive to changes in the cardiac electrical pathway after myocardial infarction as described by these graphs and parameters, and therefore MCG may be a useful tool to detect severe ischemicpatients.