| Literature DB >> 15186772 |
Andres Alonso1, Joanna Sasin, Nunzio Bottini, Ilan Friedberg, Iddo Friedberg, Andrei Osterman, Adam Godzik, Tony Hunter, Jack Dixon, Tomas Mustelin.
Abstract
Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by 90 genes in the human genome. Here, we present the set of 107 genes in the human genome that encode members of the four protein tyrosine phosphatase (PTP) families. The four families of PTPases, their substrates, structure, function, regulation, and the role of these enzymes in human disease will be discussed.Entities:
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Year: 2004 PMID： 15186772 DOI： 10.1016/j.cell.2004.05.018
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582