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Literature DB >> 19614615

53BP1: function and mechanisms of focal recruitment.

Jennifer E FitzGerald¹, Muriel Grenon, Noel F Lowndes.

Abstract

53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of 53BP1 in DNA-damage checkpoint activation and DNA repair, and the mechanisms of its recruitment and activation following DNA damage. We focus in particular on the role of covalent histone modifications in this process.

Entities: Gene

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Year: 2009 PMID： 19614615 DOI： 10.1042/BST0370897

Source DB: PubMed Journal: Biochem Soc Trans ISSN： 0300-5127 Impact factor: 5.407

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Cited

66 in total

1. The ups and downs of DNA repair biomarkers for PARP inhibitor therapies.

Authors: Xiaozhe Wang; David T Weaver
Journal: Am J Cancer Res Date: 2010-01-03 Impact factor: 6.166

2. Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells.

Authors: Sophia B Chernikova; Jennifer A Dorth; Olga V Razorenova; John C Game; J Martin Brown
Journal: Radiat Res Date: 2010-08-25 Impact factor: 2.841

3. Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation.

Authors: Steven L Sanders; Ahmad R Arida; Funita P Phan
Journal: Mol Cell Biol Date: 2010-08-02 Impact factor: 4.272

4. Heat shock protein 90α (Hsp90α) is phosphorylated in response to DNA damage and accumulates in repair foci.

Authors: Maria Quanz; Aurélie Herbette; Mano Sayarath; Leanne de Koning; Thierry Dubois; Jian-Sheng Sun; Marie Dutreix
Journal: J Biol Chem Date: 2012-01-23 Impact factor: 5.157

Review 5. Chromatin dynamics in DNA double-strand break repair.

Authors: Lei Shi; Philipp Oberdoerffer
Journal: Biochim Biophys Acta Date: 2012-01-17

6. Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.

Authors: Hisanobu Oda; Michael R Hübner; David B Beck; Michiel Vermeulen; Jerard Hurwitz; David L Spector; Danny Reinberg
Journal: Mol Cell Date: 2010-10-28 Impact factor: 17.970

53BP1: function and mechanisms of focal recruitment.

1. The ups and downs of DNA repair biomarkers for PARP inhibitor therapies.

2. Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells.

3. Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation.

4. Heat shock protein 90α (Hsp90α) is phosphorylated in response to DNA damage and accumulates in repair foci.

Review 5. Chromatin dynamics in DNA double-strand break repair.

6. Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.

7. A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair.

8. To trim or not to trim: progression and control of DSB end resection.

9. 53BP1 Contributes to Igh Locus Chromatin Topology during Class Switch Recombination.

10. Dynamics of the transcriptome response of cultured human embryonic stem cells to ionizing radiation exposure.