Literature DB >> 19608393

Effects of aging on B cell function.

Daniela Frasca1, Bonnie B Blomberg.   

Abstract

Ability to make an optimal immune response to vaccines and infectious agents declines with age in humans and animal models. Recent advances have shown intrinsic B cell defects in aged mice and humans, including decreases in Ig class switch recombination (CSR), activation-induced cytidine deaminase (AID), and E47 transcription factor. Effects on somatic hypermutation (SHM) have been varied depending on the system studied. Increase of AID in mice has shown improved CSR but not SHM. The reported microarray analysis of human B cell subsets may now be used to delineate B cell defects with aging and all the advances presented should lead to selecting agents for improved immune response in the elderly.

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Year:  2009        PMID： 19608393      PMCID： PMC2853364          DOI： 10.1016/j.coi.2009.06.001

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  56 in total

1.  Age- and tissue-specific differences in human germinal center B cell selection revealed by analysis of IgVH gene hypermutation and lineage trees.

Authors:  Monica Banerjee; Ramit Mehr; Alex Belelovsky; Jo Spencer; Deborah K Dunn-Walters
Journal:  Eur J Immunol       Date:  2002-07       Impact factor: 5.532

2.  B lymphopoiesis is active throughout human life, but there are developmental age-related changes.

Authors:  Maria Isabel D Rossi; Takafumi Yokota; Kay L Medina; Karla P Garrett; Philip C Comp; Arthur H Schipul; Paul W Kincade
Journal:  Blood       Date:  2002-08-29       Impact factor: 22.113

Review 3.  B cells as effectors.

Authors:  Michael G McHeyzer-Williams
Journal:  Curr Opin Immunol       Date:  2003-06       Impact factor: 7.486

4.  Germinal center B cells in Peyer's patches of aged mice exhibit a normal activation phenotype and highly mutated IgM genes.

Authors:  Brian J Rogerson; David P Harris; Susan L Swain; D Ollie Burgess
Journal:  Mech Ageing Dev       Date:  2003-02       Impact factor: 5.432

5.  Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice.

Authors:  Shuhua Han; Kaiyong Yang; Zeynep Ozen; Weiyi Peng; Ekaterina Marinova; Garnett Kelsoe; Biao Zheng
Journal:  J Immunol       Date:  2003-02-01       Impact factor: 5.422

6.  Specific immune responses but not basal functions of B and T cells are impaired in aged mice.

Authors:  E Speziali; A F Santiago; R M Fernandes; N M Vaz; J S Menezes; A M C Faria
Journal:  Cell Immunol       Date:  2009-02-23       Impact factor: 4.868

7.  Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice.

Authors:  Cristina Rada; Gareth T Williams; Hilde Nilsen; Deborah E Barnes; Tomas Lindahl; Michael S Neuberger
Journal:  Curr Biol       Date:  2002-10-15       Impact factor: 10.834

Review 8.  T cells and aging, January 2002 update.

Authors:  Graham Pawelec; Yvonne Barnett; Ros Forsey; Daniela Frasca; Amiela Globerson; Julie McLeod; Calogero Caruso; Claudio Franceschi; Támás Fülöp; Sudhir Gupta; Erminia Mariani; Eugenio Mocchegiani; Rafael Solana
Journal:  Front Biosci       Date:  2002-05-01

9.  E-proteins directly regulate expression of activation-induced deaminase in mature B cells.

Authors:  Camil Elie Sayegh; Melanie W Quong; Yasutoshi Agata; Cornelis Murre
Journal:  Nat Immunol       Date:  2003-04-28       Impact factor: 25.606

10.  B cells in the aged: CD27, CD5, and CD40 expression.

Authors:  Giuseppina Colonna-Romano; Matteo Bulati; Alessandra Aquino; Giuseppe Scialabba; Giuseppina Candore; Domenico Lio; Massimo Motta; Mariano Malaguarnera; Calogero Caruso
Journal:  Mech Ageing Dev       Date:  2003-04       Impact factor: 5.432
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  57 in total

Review 1.  Aging and immune function: molecular mechanisms to interventions.

Authors:  Subramaniam Ponnappan; Usha Ponnappan
Journal:  Antioxid Redox Signal       Date:  2011-01-08       Impact factor: 8.401

Review 2.  Age effects on B cells and humoral immunity in humans.

Authors:  Daniela Frasca; Alain Diaz; Maria Romero; Ana Marie Landin; Bonnie B Blomberg
Journal:  Ageing Res Rev       Date:  2010-08-20       Impact factor: 10.895

Review 3.  Aging, cytomegalovirus (CMV) and influenza vaccine responses.

Authors:  Daniela Frasca; Bonnie B Blomberg
Journal:  Hum Vaccin Immunother       Date:  2016-03-03       Impact factor: 3.452

4.  Phenotypic heterogeneity in a family with a CD40 ligand intracellular domain mutation.

Authors:  S Kiani-Alikhan; P F K Yong; K C Gilmour; D Grosse-Kreul; E G Davies; M A A Ibrahim
Journal:  J Clin Immunol       Date:  2011-10-19       Impact factor: 8.317

5.  A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice.

Authors:  Yi Hao; Patrick O'Neill; Martin S Naradikian; Jean L Scholz; Michael P Cancro
Journal:  Blood       Date:  2011-05-11       Impact factor: 22.113

Review 6.  The potential of non-myeloablative heterochronous autologous hematopoietic stem cell transplantation for extending a healthy life span.

Authors:  Primož Rožman
Journal:  Geroscience       Date:  2018-06-14       Impact factor: 7.713

Review 7.  Kidney transplantation and the ageing immune system.

Authors:  Dianne McKay; Julie Jameson
Journal:  Nat Rev Nephrol       Date:  2012-11-13       Impact factor: 28.314

Review 8.  Causes, consequences, and reversal of immune system aging.

Authors:  Encarnacion Montecino-Rodriguez; Beata Berent-Maoz; Kenneth Dorshkind
Journal:  J Clin Invest       Date:  2013-03-01       Impact factor: 14.808

9.  Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age.

Authors:  Mingcan Yu; Guangjin Li; Won-Woo Lee; Ming Yuan; Dapeng Cui; Cornelia M Weyand; Jörg J Goronzy
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-20       Impact factor: 11.205

10.  Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires.

Authors:  Chen Wang; Yi Liu; Lan T Xu; Katherine J L Jackson; Krishna M Roskin; Tho D Pham; Jonathan Laserson; Eleanor L Marshall; Katie Seo; Ji-Yeun Lee; David Furman; Daphne Koller; Cornelia L Dekker; Mark M Davis; Andrew Z Fire; Scott D Boyd
Journal:  J Immunol       Date:  2013-12-11       Impact factor: 5.422
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