Literature DB >> 19596229

Disorder, promiscuity, and toxic partnerships.

Edward M Marcotte1, Mark Tsechansky.   

Abstract

Many genes are toxic when overexpressed, but general mechanisms for this toxicity have proven elusive. Vavouri et al. (2009) find that intrinsic protein disorder and promiscuous molecular interactions are strong determinants of dosage sensitivity, explaining in part the toxicity of dosage-sensitive oncogenes in mice and humans.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19596229      PMCID： PMC2848715          DOI： 10.1016/j.cell.2009.06.024

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  8 in total

1.  Oct-3/4 is a dose-dependent oncogenic fate determinant.

Authors:  Sharon Gidekel; Galina Pizov; Yehudit Bergman; Eli Pikarsky
Journal:  Cancer Cell       Date:  2003-11       Impact factor: 31.743

2.  Biochemical and genetic analysis of the yeast proteome with a movable ORF collection.

Authors:  Daniel M Gelperin; Michael A White; Martha L Wilkinson; Yoshiko Kon; Li A Kung; Kevin J Wise; Nelson Lopez-Hoyo; Lixia Jiang; Stacy Piccirillo; Haiyuan Yu; Mark Gerstein; Mark E Dumont; Eric M Phizicky; Michael Snyder; Elizabeth J Grayhack
Journal:  Genes Dev       Date:  2005-12-01       Impact factor: 11.361

3.  A complex-based reconstruction of the Saccharomyces cerevisiae interactome.

Authors:  Haidong Wang; Boyko Kakaradov; Sean R Collins; Lena Karotki; Dorothea Fiedler; Michael Shales; Kevan M Shokat; Tobias C Walther; Nevan J Krogan; Daphne Koller
Journal:  Mol Cell Proteomics       Date:  2009-01-27       Impact factor: 5.911

4.  Functional profiling of the Saccharomyces cerevisiae genome.

Authors:  Guri Giaever; Angela M Chu; Li Ni; Carla Connelly; Linda Riles; Steeve Véronneau; Sally Dow; Ankuta Lucau-Danila; Keith Anderson; Bruno André; Adam P Arkin; Anna Astromoff; Mohamed El-Bakkoury; Rhonda Bangham; Rocio Benito; Sophie Brachat; Stefano Campanaro; Matt Curtiss; Karen Davis; Adam Deutschbauer; Karl-Dieter Entian; Patrick Flaherty; Francoise Foury; David J Garfinkel; Mark Gerstein; Deanna Gotte; Ulrich Güldener; Johannes H Hegemann; Svenja Hempel; Zelek Herman; Daniel F Jaramillo; Diane E Kelly; Steven L Kelly; Peter Kötter; Darlene LaBonte; David C Lamb; Ning Lan; Hong Liang; Hong Liao; Lucy Liu; Chuanyun Luo; Marc Lussier; Rong Mao; Patrice Menard; Siew Loon Ooi; Jose L Revuelta; Christopher J Roberts; Matthias Rose; Petra Ross-Macdonald; Bart Scherens; Greg Schimmack; Brenda Shafer; Daniel D Shoemaker; Sharon Sookhai-Mahadeo; Reginald K Storms; Jeffrey N Strathern; Giorgio Valle; Marleen Voet; Guido Volckaert; Ching-yun Wang; Teresa R Ward; Julie Wilhelmy; Elizabeth A Winzeler; Yonghong Yang; Grace Yen; Elaine Youngman; Kexin Yu; Howard Bussey; Jef D Boeke; Michael Snyder; Peter Philippsen; Ronald W Davis; Mark Johnston
Journal:  Nature       Date:  2002-07-25       Impact factor: 49.962

5.  Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.

Authors:  D Games; D Adams; R Alessandrini; R Barbour; P Berthelette; C Blackwell; T Carr; J Clemens; T Donaldson; F Gillespie
Journal:  Nature       Date:  1995-02-09       Impact factor: 49.962

6.  Mapping pathways and phenotypes by systematic gene overexpression.

Authors:  Richelle Sopko; Dongqing Huang; Nicolle Preston; Gordon Chua; Balázs Papp; Kimberly Kafadar; Mike Snyder; Stephen G Oliver; Martha Cyert; Timothy R Hughes; Charles Boone; Brenda Andrews
Journal:  Mol Cell       Date:  2006-02-03       Impact factor: 17.970

7.  Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes.

Authors:  Chad Haynes; Christopher J Oldfield; Fei Ji; Niels Klitgord; Michael E Cusick; Predrag Radivojac; Vladimir N Uversky; Marc Vidal; Lilia M Iakoucheva
Journal:  PLoS Comput Biol       Date:  2006-06-23       Impact factor: 4.475

8.  A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality.

Authors:  G Traver Hart; Insuk Lee; Edward R Marcotte
Journal:  BMC Bioinformatics       Date:  2007-07-02       Impact factor: 3.169
  8 in total
  17 in total

Review 1.  Structural metamorphism and polymorphism in proteins on the brink of thermodynamic stability.

Authors:  Prakash Kulkarni; Tsega L Solomon; Yanan He; Yihong Chen; Philip N Bryan; John Orban
Journal:  Protein Sci       Date:  2018-09-24       Impact factor: 6.725

2.  Intrinsically disordered proteins and conformational noise: implications in cancer.

Authors:  Gita Mahmoudabadi; Krithika Rajagopalan; Robert H Getzenberg; Sridhar Hannenhalli; Govindan Rangarajan; Prakash Kulkarni
Journal:  Cell Cycle       Date:  2012-12-19       Impact factor: 4.534

3.  Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity.

Authors:  Prakash Kulkarni; Mohit Kumar Jolly; Dongya Jia; Steven M Mooney; Ajay Bhargava; Luciane T Kagohara; Yihong Chen; Pengyu Hao; Yanan He; Robert W Veltri; Alexander Grishaev; Keith Weninger; Herbert Levine; John Orban
Journal:  Proc Natl Acad Sci U S A       Date:  2017-03-13       Impact factor: 11.205

4.  A majority of the cancer/testis antigens are intrinsically disordered proteins.

Authors:  Krithika Rajagopalan; Steven M Mooney; Nehal Parekh; Robert H Getzenberg; Prakash Kulkarni
Journal:  J Cell Biochem       Date:  2011-11       Impact factor: 4.429

5.  PAGE4 and Conformational Switching: Insights from Molecular Dynamics Simulations and Implications for Prostate Cancer.

Authors:  Xingcheng Lin; Susmita Roy; Mohit Kumar Jolly; Federico Bocci; Nicholas P Schafer; Min-Yeh Tsai; Yihong Chen; Yanan He; Alexander Grishaev; Keith Weninger; John Orban; Prakash Kulkarni; Govindan Rangarajan; Herbert Levine; José N Onuchic
Journal:  J Mol Biol       Date:  2018-06-05       Impact factor: 5.469

6.  The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation.

Authors:  Krithika Rajagopalan; Ruoyi Qiu; Steven M Mooney; Shweta Rao; Takumi Shiraishi; Elizabeth Sacho; Hongying Huang; Ellen Shapiro; Keith R Weninger; Prakash Kulkarni
Journal:  Biochim Biophys Acta       Date:  2013-11-18

7.  Presence and structure-activity relationship of intrinsically disordered regions across mucins.

Authors:  Joseph Carmicheal; Pranita Atri; Sunandini Sharma; Sushil Kumar; Ramakanth Chirravuri Venkata; Prakash Kulkarni; Ravi Salgia; Dario Ghersi; Sukhwinder Kaur; Surinder K Batra
Journal:  FASEB J       Date:  2020-01-05       Impact factor: 5.191

8.  Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation.

Authors:  Meng-Meng Zhang; Na Liu; Yuan-Liang Zhang; Bowen Rong; Xiao-Lin Wang; Chun-Hui Xu; Yin-Yin Xie; Shuhong Shen; Jiang Zhu; Stephen D Nimer; Zhu Chen; Sai-Juan Chen; Robert G Roeder; Fei Lan; Lan Wang; Qiu-Hua Huang; Xiao-Jian Sun
Journal:  Leukemia       Date:  2019-02-12       Impact factor: 11.528

Review 9.  Protein conformational dynamics and phenotypic switching.

Authors:  Prakash Kulkarni; Srisairam Achuthan; Supriyo Bhattacharya; Mohit Kumar Jolly; Sourabh Kotnala; Vitor B P Leite; Atish Mohanty; John Orban; Susmita Roy; Govindan Rangarajan; Ravi Salgia
Journal:  Biophys Rev       Date:  2021-11-27

10.  Generation of a genome scale lentiviral vector library for EF1α promoter-driven expression of human ORFs and identification of human genes affecting viral titer.

Authors:  Dubravka Škalamera; Mareike Dahmer; Amy S Purdon; Benjamin M Wilson; Max V Ranall; Antje Blumenthal; Brian Gabrielli; Thomas J Gonda
Journal:  PLoS One       Date:  2012-12-12       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.