PURPOSE: This study analyzed patient demographics and preoperative functional status for associations with post-cholecystectomy quality of life (QOL). METHODS: This prospective study analyzed 159 cholecystectomy patients at two tertiary academic hospitals. All patients completed the SF-36 and the gastrointestinal quality of life index (GIQLI) at baseline and at 3 and 6 months postoperatively. The 95% confidence intervals for differences in responsiveness estimates were derived by bootstrap estimation. Scores derived by these instruments were interpreted by generalized estimating equation (GEE) before and after cholecystectomy. RESULTS: The examined population significantly (p < 0.05) improved in both SF-36 subscales and GIQLI subscales. After adjusting for time effects (time, and time(2)) and baseline predictors, GEE approaches revealed the following explanatory variables for QOL: time, time(2), age, gender, preoperative GIQLI score, body mass index, and number of comorbidities. CONCLUSION: The data revealed dramatically improved post-cholecystectomy QOL. However, QOL change was simultaneously associated with preoperative functional status and demographic characteristics.
PURPOSE: This study analyzed patient demographics and preoperative functional status for associations with post-cholecystectomy quality of life (QOL). METHODS: This prospective study analyzed 159 cholecystectomy patients at two tertiary academic hospitals. All patients completed the SF-36 and the gastrointestinal quality of life index (GIQLI) at baseline and at 3 and 6 months postoperatively. The 95% confidence intervals for differences in responsiveness estimates were derived by bootstrap estimation. Scores derived by these instruments were interpreted by generalized estimating equation (GEE) before and after cholecystectomy. RESULTS: The examined population significantly (p < 0.05) improved in both SF-36 subscales and GIQLI subscales. After adjusting for time effects (time, and time(2)) and baseline predictors, GEE approaches revealed the following explanatory variables for QOL: time, time(2), age, gender, preoperative GIQLI score, body mass index, and number of comorbidities. CONCLUSION: The data revealed dramatically improved post-cholecystectomy QOL. However, QOL change was simultaneously associated with preoperative functional status and demographic characteristics.
Authors: A M Carbonell; A E Lincourt; K W Kercher; B D Matthews; W S Cobb; R F Sing; B T Heniford Journal: Surg Endosc Date: 2005-05-03 Impact factor: 4.584
Authors: Aisling M Hogan; Emir Hoti; Desmond C Winter; Paul F Ridgway; Donal Maguire; Justin G Geoghegan; Oscar Traynor Journal: Ann Surg Date: 2009-02 Impact factor: 12.969
Authors: Marc G Besselink; Niels G Venneman; Peter M Go; Ivo A Broeders; Peter D Siersema; Hein G Gooszen; Karel J van Erpecum Journal: J Gastrointest Surg Date: 2008-10-24 Impact factor: 3.452