Literature DB >> 19574634

Interaction of an echinomycin-DNA complex with manganese ions.

Roland Pfoh1, Jose A Cuesta-Seijo, George M Sheldrick.   

Abstract

The crystal structure of an echinomycin-d(ACGTACGT) duplex interacting with manganese(II) was solved by Mn-SAD using in-house data and refined to 1.1 A resolution against synchrotron data. This complex crystallizes in a different space group compared with related complexes and shows a different mode of base pairing next to the bis-intercalation site, suggesting that the energy difference between Hoogsteen and Watson-Crick pairing is rather small. The binding of manganese to N7 of guanine is only possible because of DNA unwinding induced by the echinomycin, which might help to explain the mode of action of the drug.

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Year:  2009        PMID： 19574634      PMCID： PMC2705629          DOI： 10.1107/S1744309109019654

Source DB:  PubMed          Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun        ISSN： 1744-3091


  24 in total

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4.  SHELXL: high-resolution refinement.

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5.  Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity.

Authors:  Dehe Kong; Eun Jung Park; Andrew G Stephen; Maura Calvani; John H Cardellina; Anne Monks; Robert J Fisher; Robert H Shoemaker; Giovanni Melillo
Journal:  Cancer Res       Date:  2005-10-01       Impact factor: 12.701

6.  Echinomycin: a bifunctional intercalating antibiotic.

Authors:  M J Waring; L P Wakelin
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Journal:  Chem Biodivers       Date:  2005-01       Impact factor: 2.408

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Authors:  C M Low; H R Drew; M J Waring
Journal:  Nucleic Acids Res       Date:  1984-06-25       Impact factor: 16.971

9.  A comparison of the structure of echinomycin and triostin A complexed to a DNA fragment.

Authors:  G Ughetto; A H Wang; G J Quigley; G A van der Marel; J H van Boom; A Rich
Journal:  Nucleic Acids Res       Date:  1985-04-11       Impact factor: 16.971

10.  The short-term effects on restenosis and thrombosis of echinomycin-eluting stents topcoated with a hydrophobic heparin-containing polymer.

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  8 in total

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Authors:  Allison L Stelling; Yu Xu; Huiqing Zhou; Seung H Choi; Mary C Clay; Dawn K Merriman; Hashim M Al-Hashimi
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Review 2.  New insights into Hoogsteen base pairs in DNA duplexes from a structure-based survey.

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Review 3.  The many twists and turns of DNA: template, telomere, tool, and target.

Authors:  Martin Egli; Pradeep S Pallan
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4.  Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically 13C- and 15N-Labeled DNA.

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Journal:  Biochemistry       Date:  2019-04-05       Impact factor: 3.162

5.  Cooperative recognition of T:T mismatch by echinomycin causes structural distortions in DNA duplex.

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6.  Structure of the DNA duplex d(ATTAAT)2 with Hoogsteen hydrogen bonds.

Authors:  Francisco J Acosta-Reyes; Elida Alechaga; Juan A Subirana; J Lourdes Campos
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Review 7.  A survey of recent unusual high-resolution DNA structures provoked by mismatches, repeats and ligand binding.

Authors:  Roshan Satange; Chung-Ke Chang; Ming-Hon Hou
Journal:  Nucleic Acids Res       Date:  2018-07-27       Impact factor: 16.971

8.  Encapsulation of echinomycin in cyclodextrin inclusion complexes into liposomes: in vitro anti-proliferative and anti-invasive activity in glioblastoma.

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Journal:  RSC Adv       Date:  2019-09-30       Impact factor: 4.036
  8 in total

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