| Literature DB >> 15555887 |
Jong-Bae Kim1, Gyu-Sang Lee, Yun-Bong Kim, Soo-Kie Kim, Yong Hae Kim.
Abstract
The in vitro inhibitory and bactericidal activity of echinomycin and its the novel synthetic analogues of echinomycin,YK2000 and YK2005, were evaluated using 93 clinical isolates of vancomycin-resistant enterococci (VRE). In agar dilution tests, the MIC(90) of echinomycin and YK2000 were 0.125 and 8 mg/l, respectively, using Mueller-Hinton II agar, while that of YK2005 was 32 mg/l. Bactericidal activity of echinomycin and YK2000 were two to four times higher than the MIC in time-kill assay experiments. These results suggest that echinomycin and its analogues might be useful as anti-VRE drugs.Entities:
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Year: 2004 PMID： 15555887 DOI： 10.1016/j.ijantimicag.2004.03.018
Source DB: PubMed Journal: Int J Antimicrob Agents ISSN： 0924-8579 Impact factor: 5.283