Literature DB >> 19568798

Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules.

Richard M Gunn1, Helen C Hailes.   

Abstract

This review describes the progress that has been made in understanding the PI3-K-PKB-mTOR signalling pathway by using small molecules as pharmacological probes. It briefly covers the structural characteristics, regulation of and downstream effects of several key regulators of PI3-K-PKB-mTOR signalling, then highlights the use of small molecules (by structural type) to selectively modulate specific components of the pathway.

Year:  2008        PMID： 19568798      PMCID： PMC2698322          DOI： 10.1007/s12154-008-0008-0

Source DB:  PubMed          Journal:  J Chem Biol        ISSN： 1864-6158


  63 in total

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9.  A mammalian protein targeted by G1-arresting rapamycin-receptor complex.

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Review 5.  Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals.

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  5 in total

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