| Literature DB >> 16464575 |
José-Luis Giner1, Karen A Kehbein, James A Cook, Michele C Smith, Chris J Vlahos, John A Badwey.
Abstract
Fluorescent analogs were synthesized of the potent PI 3-kinase inhibitors, wortmannin and demethoxyviridin. The esterification of 11-deacetylwortmannin, 17-hydroxywortmannin, and demethoxyviridin with the fluorescent carboxylic acids NBD-sarcosine and 7-dimethylaminocoumarin-4-acetic acid generated six novel fluorescent esters. Potent inhibition of PI 3-kinase-alpha was observed for the derivatives of 11-desacetylwortmannin and demethoxyviridin.Entities:
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Year: 2006 PMID： 16464575 DOI： 10.1016/j.bmcl.2006.01.091
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823