| Literature DB >> 19560911 |
Phyllis I Hanson1, Soomin Shim, Samuel A Merrill.
Abstract
The ESCRT (endosomal sorting complex required for transport) machinery comprises a set of protein complexes that regulate sorting and trafficking into multivesicular bodies en route to the lysosome. The physical mechanism responsible for generating lumenal vesicles in this pathway is unknown. Here we review recent studies suggesting that components of the ESCRT-III complex drive lumenal vesicle formation and consider possible mechanisms for this reaction.Entities:
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Year: 2009 PMID： 19560911 PMCID： PMC6195420 DOI： 10.1016/j.ceb.2009.06.002
Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382