Literature DB >> 19556507

Dynamic signaling network for the specification of embryonic pancreas and liver progenitors.

Ewa Wandzioch1, Kenneth S Zaret.   

Abstract

Studies of the formation of pancreas and liver progenitors have focused on individual inductive signals and cellular responses. Here, we investigated how bone morphogenetic protein, transforming growth factor-beta (TGFbeta), and fibroblast growth factor signaling pathways converge on the earliest genes that elicit pancreas and liver induction in mouse embryos. The inductive network was found to be dynamic; it changed within hours. Different signals functioned in parallel to induce different early genes, and two permutations of signals induced liver progenitor domains, which revealed flexibility in cell programming. Also, the specification of pancreas and liver progenitors was restricted by the TGFbeta pathway. These findings may enhance progenitor cell specification from stem cells for biomedical purposes and can help explain incomplete programming in stem cell differentiation protocols.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19556507      PMCID： PMC2771431          DOI： 10.1126/science.1174497

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  31 in total

1.  Initiation of mammalian liver development from endoderm by fibroblast growth factors.

Authors:  J Jung; M Zheng; M Goldfarb; K S Zaret
Journal:  Science       Date:  1999-06-18       Impact factor: 47.728

2.  Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.

Authors:  Nabeel Bardeesy; Kuang-Hung Cheng; Justin H Berger; Gerald C Chu; Jessica Pahler; Peter Olson; Aram F Hezel; James Horner; Gregory Y Lauwers; Douglas Hanahan; Ronald A DePinho
Journal:  Genes Dev       Date:  2006-11-15       Impact factor: 11.361

3.  Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues.

Authors:  Kimberly D Tremblay; Kenneth S Zaret
Journal:  Dev Biol       Date:  2005-04-01       Impact factor: 3.582

4.  An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells.

Authors:  Amélie Calmont; Ewa Wandzioch; Kimberly D Tremblay; George Minowada; Klaus H Kaestner; Gail R Martin; Kenneth S Zaret
Journal:  Dev Cell       Date:  2006-09       Impact factor: 12.270

5.  Bmp and Fgf signaling are essential for liver specification in zebrafish.

Authors:  Donghun Shin; Chong Hyun Shin; Jennifer Tucker; Elke A Ober; Fabian Rentzsch; Kenneth D Poss; Matthias Hammerschmidt; Mary C Mullins; Didier Y R Stainier
Journal:  Development       Date:  2007-06       Impact factor: 6.868

6.  Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development.

Authors:  Valérie A McLin; Scott A Rankin; Aaron M Zorn
Journal:  Development       Date:  2007-05-16       Impact factor: 6.868

7.  The initiation of liver development is dependent on Foxa transcription factors.

Authors:  Catherine S Lee; Joshua R Friedman; James T Fulmer; Klaus H Kaestner
Journal:  Nature       Date:  2005-06-16       Impact factor: 49.962

8.  Lack of TCF2/vHNF1 in mice leads to pancreas agenesis.

Authors:  C Haumaitre; E Barbacci; M Jenny; M O Ott; G Gradwohl; S Cereghini
Journal:  Proc Natl Acad Sci U S A       Date:  2005-01-24       Impact factor: 11.205

9.  BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm.

Authors:  Valerie Gouon-Evans; Lise Boussemart; Paul Gadue; Dirk Nierhoff; Christoph I Koehler; Atsushi Kubo; David A Shafritz; Gordon Keller
Journal:  Nat Biotechnol       Date:  2006-11-05       Impact factor: 54.908

10.  Notochord to endoderm signaling is required for pancreas development.

Authors:  S K Kim; M Hebrok; D A Melton
Journal:  Development       Date:  1997-11       Impact factor: 6.868
View more
  114 in total

1.  Generation of functional hepatic cells from pluripotent stem cells.

Authors:  Songyan Han; Alice Bourdon; Wissam Hamou; Noelle Dziedzic; Orit Goldman; Valerie Gouon-Evans
Journal:  J Stem Cell Res Ther       Date:  2012-08-15

2.  Biliary tree stem/progenitor cells in glands of extrahepatic and intraheptic bile ducts: an anatomical in situ study yielding evidence of maturational lineages.

Authors:  Guido Carpino; Vincenzo Cardinale; Paolo Onori; Antonio Franchitto; Pasquale Bartolomeo Berloco; Massimo Rossi; Yunfang Wang; Rossella Semeraro; Maurizio Anceschi; Roberto Brunelli; Domenico Alvaro; Lola M Reid; Eugenio Gaudio
Journal:  J Anat       Date:  2011-12-05       Impact factor: 2.610

Review 3.  The biliary tree--a reservoir of multipotent stem cells.

Authors:  Vincenzo Cardinale; Yunfang Wang; Guido Carpino; Gemma Mendel; Gianfranco Alpini; Eugenio Gaudio; Lola M Reid; Domenico Alvaro
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2012-02-28       Impact factor: 46.802

4.  Growth factor- and cytokine-driven pathways governing liver stemness and differentiation.

Authors:  Aránzazu Sánchez; Isabel Fabregat
Journal:  World J Gastroenterol       Date:  2010-11-07       Impact factor: 5.742

5.  Patterning of the hepato-pancreatobiliary boundary by BMP reveals heterogeneity within the murine liver bud.

Authors:  Amrita Palaria; Jesse R Angelo; Taylor M Guertin; Jesse Mager; Kimberly D Tremblay
Journal:  Hepatology       Date:  2018-05-09       Impact factor: 17.425

6.  Homeoprotein hhex-induced conversion of intestinal to ventral pancreatic precursors results in the formation of giant pancreata in Xenopus embryos.

Authors:  Hui Zhao; Dandan Han; Igor B Dawid; Tomas Pieler; Yonglong Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-16       Impact factor: 11.205

Review 7.  Chromatin "pre-pattern" and epigenetic modulation in the cell fate choice of liver over pancreas in the endoderm.

Authors:  Cheng-Ran Xu; Kenneth S Zaret
Journal:  Nucleus       Date:  2012-03-01       Impact factor: 4.197

Review 8.  Setting appropriate boundaries: fate, patterning and competence at the neural plate border.

Authors:  Andrew K Groves; Carole LaBonne
Journal:  Dev Biol       Date:  2013-12-07       Impact factor: 3.582

Review 9.  Model systems and experimental conditions that lead to effective repopulation of the liver by transplanted cells.

Authors:  David A Shafritz; Michael Oertel
Journal:  Int J Biochem Cell Biol       Date:  2010-01-18       Impact factor: 5.085

10.  Progenitor cell niches in the human pancreatic duct system and associated pancreatic duct glands: an anatomical and immunophenotyping study.

Authors:  Guido Carpino; Anastasia Renzi; Vincenzo Cardinale; Antonio Franchitto; Paolo Onori; Diletta Overi; Massimo Rossi; Pasquale Bartolomeo Berloco; Domenico Alvaro; Lola M Reid; Eugenio Gaudio
Journal:  J Anat       Date:  2015-11-27       Impact factor: 2.610
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.