Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Chromatin "pre-pattern" and epigenetic modulation in the cell fate choice of liver over pancreas in the endoderm.

Literature DB >> 22555599

Chromatin "pre-pattern" and epigenetic modulation in the cell fate choice of liver over pancreas in the endoderm.

Abstract

Understanding the basis for multipotency, whereby stem cells and other progenitors can differentiate into certain tissues and not others, provides insights into the mechanism of cell programming in development, homeostasis, and disease. We recently reported a screen of diverse chromatin marks to obtain clues about chromatin states in the multipotent embryonic endoderm. Genetic and pharmacologic tests of certain marks' function demonstrated that the relevant chromatin modifying factors modulate the fate choice for liver or pancreas induction in the endoderm. The information about chromatin states from embryonic studies can be used to predict lineage-specific developmental potential and chromatin modifiers to enhance particular cell fate transitions from stem cells.

Mesh：

Substances：
Chromatin

Year: 2012 PMID： 22555599 PMCID： PMC3383570 DOI： 10.4161/nucl.19321

Source DB: PubMed Journal: Nucleus ISSN： 1949-1034 Impact factor: 4.197

61 in total

1. Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas.

Authors: Roque Bort; Juan Pedro Martinez-Barbera; Rosa S P Beddington; Kenneth S Zaret
Journal: Development Date: 2004-01-21 Impact factor: 6.868

2. Role of histone H3 lysine 27 methylation in Polycomb-group silencing.

Authors: Ru Cao; Liangjun Wang; Hengbin Wang; Li Xia; Hediye Erdjument-Bromage; Paul Tempst; Richard S Jones; Yi Zhang
Journal: Science Date: 2002-09-26 Impact factor: 47.728

3. Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo.

Authors: Gerald C Chu; N Ray Dunn; Dorian C Anderson; Leif Oxburgh; Elizabeth J Robertson
Journal: Development Date: 2004-06-23 Impact factor: 6.868

4. Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control.

Authors: R Gualdi; P Bossard; M Zheng; Y Hamada; J R Coleman; K S Zaret
Journal: Genes Dev Date: 1996-07-01 Impact factor: 11.361

5. Physical and functional interaction of SMADs and p300/CBP.

Authors: C Pouponnot; L Jayaraman; J Massagué
Journal: J Biol Chem Date: 1998-09-04 Impact factor: 5.157

6. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300.

Authors: T P Yao; S P Oh; M Fuchs; N D Zhou; L E Ch'ng; D Newsome; R T Bronson; E Li; D M Livingston; R Eckner
Journal: Cell Date: 1998-05-01 Impact factor: 41.582

7. The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade.

Authors: Patrick Jacquemin; Frédéric P Lemaigre; Guy G Rousseau
Journal: Dev Biol Date: 2003-06-01 Impact factor: 3.582

8. Insulin-promoter-factor 1 is required for pancreas development in mice.

Authors: J Jonsson; L Carlsson; T Edlund; H Edlund
Journal: Nature Date: 1994-10-13 Impact factor: 49.962

9. Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny.

Authors: Y Guz; M R Montminy; R Stein; J Leonard; L W Gamer; C V Wright; G Teitelman
Journal: Development Date: 1995-01 Impact factor: 6.868

Chromatin "pre-pattern" and epigenetic modulation in the cell fate choice of liver over pancreas in the endoderm.

1. Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas.

2. Role of histone H3 lysine 27 methylation in Polycomb-group silencing.

3. Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo.

4. Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control.

5. Physical and functional interaction of SMADs and p300/CBP.

6. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300.

7. The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade.

8. Insulin-promoter-factor 1 is required for pancreas development in mice.

9. Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny.

10. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum.

Review 1. The roles and regulation of Polycomb complexes in neural development.

2. A negative feedback loop of transcription factors specifies alternative dendritic cell chromatin States.

Review 3. Regulation of liver development: implications for liver biology across the lifespan.

Review 4. Epigenetics and epitranscriptomics in temporal patterning of cortical neural progenitor competence.