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Literature DB >> 19556499

The increasing complexity of the cancer stem cell paradigm.

Abstract

The investigation and study of cancer stem cells (CSCs) have received enormous attention over the past 5 to 10 years but remain topics of considerable controversy. Opinions about the validity of the CSC hypothesis, the biological properties of CSCs, and the relevance of CSCs to cancer therapy differ widely. In the following commentary, we discuss the nature of the debate, the parameters by which CSCs can or cannot be defined, and the identification of new potential therapeutic targets elucidated by considering cancer as a problem in stem cell biology.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2009 PMID： 19556499 PMCID： PMC2873047 DOI： 10.1126/science.1171837

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

37 in total

1. Cancer: Inflaming metastasis.

Authors: Alberto Mantovani
Journal: Nature Date: 2009-01-01 Impact factor: 49.962

Review 2. Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?

Authors: Mina J Bissell; Mark A Labarge
Journal: Cancer Cell Date: 2005-01 Impact factor: 31.743

Review 3. Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression.

Authors: Thomas Brabletz; Andreas Jung; Simone Spaderna; Falk Hlubek; Thomas Kirchner
Journal: Nat Rev Cancer Date: 2005-09 Impact factor: 60.716

4. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.

Authors: D Bonnet; J E Dick
Journal: Nat Med Date: 1997-07 Impact factor: 53.440

5. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.

Authors: Monica L Guzman; Randall M Rossi; Lilliana Karnischky; Xiaojie Li; Derick R Peterson; Dianna S Howard; Craig T Jordan
Journal: Blood Date: 2005-02-01 Impact factor: 22.113

6. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells.

Authors: Omer H Yilmaz; Riccardo Valdez; Brian K Theisen; Wei Guo; David O Ferguson; Hong Wu; Sean J Morrison
Journal: Nature Date: 2006-04-05 Impact factor: 49.962

Review 7. On mammary stem cells.

Authors: Wendy A Woodward; Mercy S Chen; Fariba Behbod; Jeffrey M Rosen
Journal: J Cell Sci Date: 2005-08-15 Impact factor: 5.285

8. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice.

Authors: T Lapidot; C Sirard; J Vormoor; B Murdoch; T Hoang; J Caceres-Cortes; M Minden; B Paterson; M A Caligiuri; J E Dick
Journal: Nature Date: 1994-02-17 Impact factor: 49.962

9. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia.

Authors: Chen Zhao; Alan Chen; Catriona H Jamieson; Mark Fereshteh; Annelie Abrahamsson; Jordan Blum; Hyog Young Kwon; Jynho Kim; John P Chute; David Rizzieri; Michael Munchhof; Todd VanArsdale; Philip A Beachy; Tannishtha Reya
Journal: Nature Date: 2009-04-09 Impact factor: 49.962

10. Identification of human brain tumour initiating cells.

Authors: Sheila K Singh; Cynthia Hawkins; Ian D Clarke; Jeremy A Squire; Jane Bayani; Takuichiro Hide; R Mark Henkelman; Michael D Cusimano; Peter B Dirks
Journal: Nature Date: 2004-11-18 Impact factor: 49.962

319 in total

Review 1. Cancer stem cells: a stride towards cancer cure?

Authors: Amitava Sengupta; Jose A Cancelas
Journal: J Cell Physiol Date: 2010-10 Impact factor: 6.384

2. The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.

Authors: Lauren L C Marotta; Vanessa Almendro; Andriy Marusyk; Michail Shipitsin; Janina Schemme; Sarah R Walker; Noga Bloushtain-Qimron; Jessica J Kim; Sibgat A Choudhury; Reo Maruyama; Zhenhua Wu; Mithat Gönen; Laura A Mulvey; Marina O Bessarabova; Sung Jin Huh; Serena J Silver; So Young Kim; So Yeon Park; Hee Eun Lee; Karen S Anderson; Andrea L Richardson; Tatiana Nikolskaya; Yuri Nikolsky; X Shirley Liu; David E Root; William C Hahn; David A Frank; Kornelia Polyak
Journal: J Clin Invest Date: 2011-07 Impact factor: 14.808

3. Leptin deficiency suppresses MMTV-Wnt-1 mammary tumor growth in obese mice and abrogates tumor initiating cell survival.

Authors: Qiao Zheng; Sarah M Dunlap; Jinling Zhu; Erinn Downs-Kelly; Jeremy Rich; Stephen D Hursting; Nathan A Berger; Ofer Reizes
Journal: Endocr Relat Cancer Date: 2011-07-11 Impact factor: 5.678

The increasing complexity of the cancer stem cell paradigm.

1. Cancer: Inflaming metastasis.

Review 2. Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?

Review 3. Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression.

4. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.

5. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.

6. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells.

Review 7. On mammary stem cells.

8. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice.

9. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia.

10. Identification of human brain tumour initiating cells.

Review 1. Cancer stem cells: a stride towards cancer cure?

2. The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.

3. Leptin deficiency suppresses MMTV-Wnt-1 mammary tumor growth in obese mice and abrogates tumor initiating cell survival.

4. Stem cell pathways contribute to clinical chemoresistance in ovarian cancer.

5. Selective inhibitory effect of HPMA copolymer-cyclopamine conjugate on prostate cancer stem cells.

6. HSV Recombinant Vectors for Gene Therapy.

Review 7. Molecular mechanism of pancreatic cancer--understanding proliferation, invasion, and metastasis.

8. Prognostic value of periostin in early-stage breast cancer treated with conserving surgery and radiotherapy.

Review 9. Cancer stem cells and radioresistance.

10. An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state.