OBJECTIVE: To examine an association between persistent metabolic syndrome (MetS) and the risk for type 2 diabetes in overweight Hispanic children. STUDY DESIGN: A total of 73 subjects (mean age, 11.0 +/- 1.7 years) from a longitudinal study were classified as Never (negative for MetS at all 3 annual visits), Intermittent (positive for MetS at 1 or 2 visits), or Persistent (positive for MetS at all 3 visits). Measures included dual-energy x-ray absorptiometry, magnetic resonance imaging, the 2-hour oral glucose tolerance test, and the frequently sampled intravenous glucose tolerance test. RESULTS: The Persistent group had a faster rate of fat mass gain than the Never group (20% vs 15% gain of baseline value; P < .05 for time *group interaction [time = visit]). Independent of body composition, the Persistent group increased by 70% in insulin incremental area under the curve, whereas the other groups decreased (P < .05 for time *group interaction). Despite no time *group interactions for insulin sensitivity, acute insulin response, or disposition index, the Persistent group maintained 43% lower insulin sensitivity (P < .01) and by visit 2 had a 25% lower disposition index (P < .05) compared with the Never group. CONCLUSIONS: Patients with persistent MetS had accelerated fat gain, increased insulin response to oral glucose, and decreased sensitivity and beta cell function, indicators of progressively greater risk for type 2 diabetes.
OBJECTIVE: To examine an association between persistent metabolic syndrome (MetS) and the risk for type 2 diabetes in overweight Hispanic children. STUDY DESIGN: A total of 73 subjects (mean age, 11.0 +/- 1.7 years) from a longitudinal study were classified as Never (negative for MetS at all 3 annual visits), Intermittent (positive for MetS at 1 or 2 visits), or Persistent (positive for MetS at all 3 visits). Measures included dual-energy x-ray absorptiometry, magnetic resonance imaging, the 2-hour oral glucose tolerance test, and the frequently sampled intravenous glucose tolerance test. RESULTS: The Persistent group had a faster rate of fat mass gain than the Never group (20% vs 15% gain of baseline value; P < .05 for time *group interaction [time = visit]). Independent of body composition, the Persistent group increased by 70% in insulin incremental area under the curve, whereas the other groups decreased (P < .05 for time *group interaction). Despite no time *group interactions for insulin sensitivity, acute insulin response, or disposition index, the Persistent group maintained 43% lower insulin sensitivity (P < .01) and by visit 2 had a 25% lower disposition index (P < .05) compared with the Never group. CONCLUSIONS:Patients with persistent MetS had accelerated fat gain, increased insulin response to oral glucose, and decreased sensitivity and beta cell function, indicators of progressively greater risk for type 2 diabetes.
Authors: Michael I Goran; Kate Coronges; Richard N Bergman; Martha L Cruz; Barbara A Gower Journal: J Clin Endocrinol Metab Date: 2003-01 Impact factor: 5.958
Authors: Sarvenaz Vandyousefi; Michael I Goran; Erica P Gunderson; Erfan Khazaee; Matthew J Landry; Reem Ghaddar; Fiona M Asigbee; Jaimie N Davis Journal: Pediatr Obes Date: 2019-02-08 Impact factor: 4.000
Authors: B R Belcher; C-P Chou; S T Nguyen-Rodriguez; Y-W Hsu; C E Byrd-Williams; A D McClain; M J Weigensberg; D Spuijt-Metz Journal: Pediatr Obes Date: 2012-09-19 Impact factor: 4.000
Authors: Yann C Klimentidis; Jasmin Divers; Krista Casazza; T Mark Beasley; David B Allison; Jose R Fernandez Journal: Hum Genomics Date: 2011-01 Impact factor: 4.639