BACKGROUND: The effects of breastfeeding (BF) on metabolic syndrome (MetS) and diabetes mellitus in children exposed to gestational diabetes mellitus (GDM) in utero have rarely been evaluated. OBJECTIVE: This study assessed BF and GDM in relation to the prevalence of prediabetes and MetS in Hispanic children and adolescents (8-19 y). METHODS: This is a longitudinal study with 229 Hispanic children (8-13 y) with overweight/obesity, family history of diabetes, and an average of four annual visits (AV). Participants were categorized as follows: never (negative for prediabetes/MetS at all AVs), ever (positive for prediabetes/MetS at any visit), intermittent (positive for prediabetes/MetS at 1-2 AVs), and persistent (positive for prediabetes/MetS at greater than or equal to 3 AVs). RESULTS: Compared with GDM offspring who were not BF (referent), GDM offspring who were BF had lower odds of persistent prediabetes (OR = 0.18; 95% CI, 0.04-0.82; P = 0.02) and MetS (OR = 0.10; 95% CI, 0.02-0.55; P = 0.008). Compared with referent group, non-GDM offspring who were BF, and non-GDM offspring not BF had lower odds of persistent prediabetes (OR = 0.10; 95% CI, 0.03-0.39; P = 0.001; OR = 0.05; 95% CI, 0.01-0.11; P < 0.001) and MetS (OR = 0.14; 95% CI, 0.04-0.59; P = 0.01 and OR = 0.04; 95% CI, 0.01-0.11; P < 0.001). CONCLUSIONS: These results show BF is protective against prediabetes and MetS in offspring regardless of GDM status.
BACKGROUND: The effects of breastfeeding (BF) on metabolic syndrome (MetS) and diabetes mellitus in children exposed to gestational diabetes mellitus (GDM) in utero have rarely been evaluated. OBJECTIVE: This study assessed BF and GDM in relation to the prevalence of prediabetes and MetS in Hispanic children and adolescents (8-19 y). METHODS: This is a longitudinal study with 229 Hispanic children (8-13 y) with overweight/obesity, family history of diabetes, and an average of four annual visits (AV). Participants were categorized as follows: never (negative for prediabetes/MetS at all AVs), ever (positive for prediabetes/MetS at any visit), intermittent (positive for prediabetes/MetS at 1-2 AVs), and persistent (positive for prediabetes/MetS at greater than or equal to 3 AVs). RESULTS: Compared with GDM offspring who were not BF (referent), GDM offspring who were BF had lower odds of persistent prediabetes (OR = 0.18; 95% CI, 0.04-0.82; P = 0.02) and MetS (OR = 0.10; 95% CI, 0.02-0.55; P = 0.008). Compared with referent group, non-GDM offspring who were BF, and non-GDM offspring not BF had lower odds of persistent prediabetes (OR = 0.10; 95% CI, 0.03-0.39; P = 0.001; OR = 0.05; 95% CI, 0.01-0.11; P < 0.001) and MetS (OR = 0.14; 95% CI, 0.04-0.59; P = 0.01 and OR = 0.04; 95% CI, 0.01-0.11; P < 0.001). CONCLUSIONS: These results show BF is protective against prediabetes and MetS in offspring regardless of GDM status.
Authors: Jennifer T Smilowitz; Carlito B Lebrilla; David A Mills; J Bruce German; Samara L Freeman Journal: Annu Rev Nutr Date: 2014-05-15 Impact factor: 11.848
Authors: Shin Y Kim; Carina Saraiva; Michael Curtis; Hoyt G Wilson; Jennifer Troyan; Andrea J Sharma Journal: Am J Public Health Date: 2013-08-15 Impact factor: 9.308
Authors: Emily E Ventura; Christianne J Lane; Marc J Weigensberg; Claudia M Toledo-Corral; Jaimie N Davis; Michael I Goran Journal: J Pediatr Date: 2009-06-24 Impact factor: 4.406
Authors: Yi Ying Ong; Wei Wei Pang; Jonathan Y Huang; Izzuddin M Aris; Suresh Anand Sadananthan; Mya-Thway Tint; Wen Lun Yuan; Ling-Wei Chen; Yiong Huak Chan; Neerja Karnani; S Sendhil Velan; Marielle V Fortier; Jonathan Choo; Lieng Hsi Ling; Lynette Shek; Kok Hian Tan; Peter D Gluckman; Fabian Yap; Yap-Seng Chong; Keith M Godfrey; Mary F-F Chong; Shiao-Yng Chan; Johan G Eriksson; Mary E Wlodek; Yung Seng Lee; Navin Michael Journal: Eur J Nutr Date: 2022-02-06 Impact factor: 4.865
Authors: Jayne F Martin Carli; G Devon Trahan; Kenneth L Jones; Nicole Hirsch; Kristy P Rolloff; Emily Z Dunn; Jacob E Friedman; Linda A Barbour; Teri L Hernandez; Paul S MacLean; Jenifer Monks; James L McManaman; Michael C Rudolph Journal: J Mammary Gland Biol Neoplasia Date: 2020-11-20 Impact factor: 2.673