Literature DB >> 9215613

Synthesis and cytotoxic activity of indolyl thiazoles.

C J Moody1, J R Roffey, M A Stephens, I J Stratford.   

Abstract

A number of indolyl thiazoles have been prepared and evaluated for their antitumor properties. The compounds were synthesized from the appropriate indole, building up the thiazole ring using the Hantzsch reaction. Cytotoxic activity was measured in the human breast cancer cell line SKBr3 using the MTT assay.

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Year:  1997        PMID： 9215613     DOI： 10.1097/00001813-199706000-00012

Source DB:  PubMed          Journal:  Anticancer Drugs        ISSN： 0959-4973            Impact factor:   2.248


  7 in total

1.  Automated Multistep Continuous Flow Synthesis of 2-(1H-Indol-3-yl)thiazole Derivatives.

Authors:  Nicholas Pagano; Marintha L Heil; Nicholas D P Cosford
Journal:  Synthesis (Stuttg)       Date:  2012       Impact factor: 3.157

2.  Minimum set of cytochromes P450 for reconstituting the biosynthesis of camalexin, a major Arabidopsis antibiotic.

Authors:  Andrew P Klein; Gülbenk Anarat-Cappillino; Elizabeth S Sattely
Journal:  Angew Chem Int Ed Engl       Date:  2013-10-21       Impact factor: 15.336

3.  Camalexin induces apoptosis in T-leukemia Jurkat cells by increased concentration of reactive oxygen species and activation of caspase-8 and caspase-9.

Authors:  Roman Mezencev; Taylor Updegrove; Peter Kutschy; Mária Repovská; John F McDonald
Journal:  J Nat Med       Date:  2011-03-19       Impact factor: 2.343

4.  The phytoalexin camalexin mediates cytotoxicity towards aggressive prostate cancer cells via reactive oxygen species.

Authors:  Basil A Smith; Corey L Neal; Mahandranauth Chetram; BaoHan Vo; Roman Mezencev; Cimona Hinton; Valerie A Odero-Marah
Journal:  J Nat Med       Date:  2012-11-24       Impact factor: 2.343

5.  Trypanosoma cruzi: antiproliferative effect of indole phytoalexins on intracellular amastigotes in vitro.

Authors:  Roman Mezencev; Melina Galizzi; Peter Kutschy; Roberto Docampo
Journal:  Exp Parasitol       Date:  2009-02-01       Impact factor: 2.011

6.  Camalexin-induced apoptosis in prostate cancer cells involves alterations of expression and activity of lysosomal protease cathepsin D.

Authors:  Basil Smith; Diandra Randle; Roman Mezencev; LeeShawn Thomas; Cimona Hinton; Valerie Odero-Marah
Journal:  Molecules       Date:  2014-04-02       Impact factor: 4.411

7.  One-pot synthesis and in-vitro anticancer evaluation of 5-(2'-indolyl)thiazoles.

Authors:  Buchi Reddy Vaddula; Mukund P Tantak; Rachana Sadana; Michael A Gonzalez; Dalip Kumar
Journal:  Sci Rep       Date:  2016-03-29       Impact factor: 4.379
  7 in total

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