Literature DB >> 19545208

Importance of the epa locus of Enterococcus faecalis OG1RF in a mouse model of ascending urinary tract infection.

Kavindra V Singh1, Roshan J Lewis, Barbara E Murray.   

Abstract

Previously, TX5179, a disruption mutant of the enterococcal polysaccharide antigen (epa) gene cluster of Enterococcus faecalis strain OG1RF was shown to be attenuated in translocation, biofilm, mouse peritonitis and was more susceptible to polymorphonuclear leukocyte phagocytic killing. Here, wild-type E. faecalis OG1RF and TX5179 strains were tested in a mixed-infection (inoculum, approximately 1:1) mouse urinary tract infection model. Wild-type OG1RF outnumbered TX5179 in the kidneys (P < .001) and bladder (P < .001). In conclusion, the epa locus of E. faecalis OG1RF contributes to murine urinary tract infection and is the first such enterococcal polysaccharide locus shown to be important in this site.

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Year:  2009        PMID： 19545208      PMCID： PMC3615707          DOI： 10.1086/600124

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  15 in total

1.  Analysis of a gene cluster of Enterococcus faecalis involved in polysaccharide biosynthesis.

Authors:  Y Xu; K V Singh; X Qin; B E Murray; G M Weinstock
Journal:  Infect Immun       Date:  2000-02       Impact factor: 3.441

2.  Endocarditis and biofilm-associated pili of Enterococcus faecalis.

Authors:  Sreedhar R Nallapareddy; Kavindra V Singh; Jouko Sillanpää; Danielle A Garsin; Magnus Höök; Stanley L Erlandsen; Barbara E Murray
Journal:  J Clin Invest       Date:  2006-10       Impact factor: 14.808

3.  Role of Enterococcus faecalis surface protein Esp in the pathogenesis of ascending urinary tract infection.

Authors:  N Shankar; C V Lockatell; A S Baghdayan; C Drachenberg; M S Gilmore; D E Johnson
Journal:  Infect Immun       Date:  2001-07       Impact factor: 3.441

4.  Enterococcus faecalis tropism for the kidneys in the urinary tract of C57BL/6J mice.

Authors:  Andrew L Kau; Steven M Martin; William Lyon; Ericka Hayes; Michael G Caparon; Scott J Hultgren
Journal:  Infect Immun       Date:  2005-04       Impact factor: 3.441

5.  Prophylactic and therapeutic efficacy of antibodies to a capsular polysaccharide shared among vancomycin-sensitive and -resistant enterococci.

Authors:  J Huebner; A Quaas; W A Krueger; D A Goldmann; G B Pier
Journal:  Infect Immun       Date:  2000-08       Impact factor: 3.441

6.  Importance of the ebp (endocarditis- and biofilm-associated pilus) locus in the pathogenesis of Enterococcus faecalis ascending urinary tract infection.

Authors:  Kavindra V Singh; Sreedhar R Nallapareddy; Barbara E Murray
Journal:  J Infect Dis       Date:  2007-04-26       Impact factor: 5.226

7.  Serum dependent expression of Enterococcus faecalis adhesins involved in the colonization of heart cells.

Authors:  C A Guzmàn; C Pruzzo; M Platè; M C Guardati; L Calegari
Journal:  Microb Pathog       Date:  1991-12       Impact factor: 3.738

8.  Role played by serum, a biological cue, in the adherence of Enterococcus faecalis to extracellular matrix proteins, collagen, fibrinogen, and fibronectin.

Authors:  Sreedhar R Nallapareddy; Barbara E Murray
Journal:  J Infect Dis       Date:  2008-06-15       Impact factor: 5.226

Review 9.  Cell adhesion molecules and extracellular-matrix constituents in kidney development and disease.

Authors:  U Müller; A W Brändli
Journal:  J Cell Sci       Date:  1999-11       Impact factor: 5.285

10.  Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF.

Authors:  Agathe Bourgogne; Danielle A Garsin; Xiang Qin; Kavindra V Singh; Jouko Sillanpaa; Shailaja Yerrapragada; Yan Ding; Shannon Dugan-Rocha; Christian Buhay; Hua Shen; Guan Chen; Gabrielle Williams; Donna Muzny; Arash Maadani; Kristina A Fox; Jason Gioia; Lei Chen; Yue Shang; Cesar A Arias; Sreedhar R Nallapareddy; Meng Zhao; Vittal P Prakash; Shahreen Chowdhury; Huaiyang Jiang; Richard A Gibbs; Barbara E Murray; Sarah K Highlander; George M Weinstock
Journal:  Genome Biol       Date:  2008-07-08       Impact factor: 13.583
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  20 in total

1.  Characterization of the ebp(fm) pilus-encoding operon of Enterococcus faecium and its role in biofilm formation and virulence in a murine model of urinary tract infection.

Authors:  Jouko Sillanpää; Sreedhar R Nallapareddy; Kavindra V Singh; Vittal P Prakash; Timothy Fothergill; Hung Ton-That; Barbara E Murray
Journal:  Virulence       Date:  2010 Jul-Aug       Impact factor: 5.882

Review 2.  The rise of the Enterococcus: beyond vancomycin resistance.

Authors:  Cesar A Arias; Barbara E Murray
Journal:  Nat Rev Microbiol       Date:  2012-03-16       Impact factor: 60.633

Review 3.  Pathogenicity of Enterococci.

Authors:  Elizabeth Fiore; Daria Van Tyne; Michael S Gilmore
Journal:  Microbiol Spectr       Date:  2019-07

4.  Response of corneal epithelial cells to Staphylococcus aureus.

Authors:  Susan R Heimer; Ai Yamada; Hugh Russell; Michael Gilmore
Journal:  Virulence       Date:  2010 Jul-Aug       Impact factor: 5.882

5.  Efficacy of ceftobiprole Medocaril against Enterococcus faecalis in a murine urinary tract infection model.

Authors:  Kavindra V Singh; Barbara E Murray
Journal:  Antimicrob Agents Chemother       Date:  2012-03-26       Impact factor: 5.191

6.  Molecular epidemiology of vancomycin-resistant Enterococcus faecium: a prospective, multicenter study in South American hospitals.

Authors:  Diana Panesso; Jinnethe Reyes; Sandra Rincón; Lorena Díaz; Jessica Galloway-Peña; Jeannete Zurita; Carlos Carrillo; Altagracia Merentes; Manuel Guzmán; Javier A Adachi; Barbara E Murray; Cesar A Arias
Journal:  J Clin Microbiol       Date:  2010-03-10       Impact factor: 5.948

7.  Loss of a Major Enterococcal Polysaccharide Antigen (Epa) by Enterococcus faecalis Is Associated with Increased Resistance to Ceftriaxone and Carbapenems.

Authors:  Kavindra V Singh; Barbara E Murray
Journal:  Antimicrob Agents Chemother       Date:  2019-04-25       Impact factor: 5.191

8.  Comparative genomic analysis of pathogenic and probiotic Enterococcus faecalis isolates, and their transcriptional responses to growth in human urine.

Authors:  Heidi C Vebø; Margrete Solheim; Lars Snipen; Ingolf F Nes; Dag A Brede
Journal:  PLoS One       Date:  2010-08-31       Impact factor: 3.240

9.  The transcriptome of the nosocomial pathogen Enterococcus faecalis V583 reveals adaptive responses to growth in blood.

Authors:  Heidi C Vebø; Lars Snipen; Ingolf F Nes; Dag A Brede
Journal:  PLoS One       Date:  2009-11-04       Impact factor: 3.240

10.  Frequency of ace, epa and elrA Genes in Clinical and Environmental Strains of Enterococcus faecalis.

Authors:  Monika Eliza Lysakowska; Andrzej Denys; Monika Sienkiewicz
Journal:  Indian J Microbiol       Date:  2012-06-22       Impact factor: 2.461
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