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Literature DB >> 19536192

A novel modifier of regulatory T cells.

Abstract

The receptor for the lipid mediator sphingosine 1-phosphate is critical for T cell trafficking. New data show that signaling mediated by this receptor critically controls the development, maintenance and suppressive activity of natural regulatory T cells that express the transcription factor Foxp3.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2009 PMID： 19536192 DOI： 10.1038/ni0709-685

Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606

12 in total

Review 1. Toll-like receptors on regulatory T cells: expanding immune regulation.

Authors: Roger P M Sutmuller; Mary E Morgan; Mihai G Netea; Oliver Grauer; Gosse J Adema
Journal: Trends Immunol Date: 2006-06-30 Impact factor: 16.687

Review 2. FTY720: a most promising immunosuppressant modulating immune cell functions.

Authors: Zhiren Zhang; Hermann J Schluesener
Journal: Mini Rev Med Chem Date: 2007-08 Impact factor: 3.862

Review 3. Regulatory T cells and immune tolerance.

Authors: Shimon Sakaguchi; Tomoyuki Yamaguchi; Takashi Nomura; Masahiro Ono
Journal: Cell Date: 2008-05-30 Impact factor: 41.582

4. The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors.

Authors: Shawn G Payne; Carole A Oskeritzian; Rachael Griffiths; Preeti Subramanian; Suzanne E Barbour; Charles E Chalfant; Sheldon Milstien; Sarah Spiegel
Journal: Blood Date: 2006-09-28 Impact factor: 22.113

5. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1.

Authors: Mehrdad Matloubian; Charles G Lo; Guy Cinamon; Matthew J Lesneski; Ying Xu; Volker Brinkmann; Maria L Allende; Richard L Proia; Jason G Cyster
Journal: Nature Date: 2004-01-22 Impact factor: 49.962

6. CD28 costimulation is essential for human T regulatory expansion and function.

Authors: Tatiana N Golovina; Tatiana Mikheeva; Megan M Suhoski; Nicole A Aqui; Victoria C Tai; Xiaochuan Shan; Ronghua Liu; R Robert Balcarcel; Nancy Fisher; Bruce L Levine; Richard G Carroll; Noel Warner; Bruce R Blazar; Carl H June; James L Riley
Journal: J Immunol Date: 2008-08-15 Impact factor: 5.422

7. Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells.

Authors: W Gao; Y Lu; B El Essawy; M Oukka; V K Kuchroo; T B Strom
Journal: Am J Transplant Date: 2007-05-19 Impact factor: 8.086

8. Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells.

Authors: Daniel T Patton; Oliver A Garden; Wayne P Pearce; Louise E Clough; Clare R Monk; Eva Leung; Wendy C Rowan; Sara Sancho; Lucy S K Walker; Bart Vanhaesebroeck; Klaus Okkenhaug
Journal: J Immunol Date: 2006-11-15 Impact factor: 5.422

A novel modifier of regulatory T cells.

Review 1. Toll-like receptors on regulatory T cells: expanding immune regulation.

Review 2. FTY720: a most promising immunosuppressant modulating immune cell functions.

Review 3. Regulatory T cells and immune tolerance.

4. The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors.

5. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1.

6. CD28 costimulation is essential for human T regulatory expansion and function.

7. Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells.

8. Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells.

9. The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.

10. The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells.

Review 1. Kinase AKT controls innate immune cell development and function.

2. TSC1/2 signaling complex is essential for peripheral naïve CD8+ T cell survival and homeostasis in mice.

3. Prediction of antiviral efficacy in patients with chronic hepatitis C by changes in forkhead box protein 3 levels.