Literature DB >> 17692046

FTY720: a most promising immunosuppressant modulating immune cell functions.

Zhiren Zhang1, Hermann J Schluesener.   

Abstract

FTY720, the pharmacological analog of S1P, acts as an agonist of sphingosine-1-phosphate receptors, resulting in the inhibition of lymphocyte egress from secondary lymphoid tissues and thymocytes from the thymus, peripheral lymphopenia and interfering with normal functions of several other cell types. FTY720 has been clinically tried for transplantation and multiple sclerosis, showing promising protective effects. This review will summarize potential applications and effects of FTY720.

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Year:  2007        PMID： 17692046     DOI： 10.2174/138955707781387948

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  10 in total

1.  Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720.

Authors:  Xuequan Lu; Chaode Sun; William J Valentine; E Shuyu; Jianxiong Liu; Gabor Tigyi; Robert Bittman
Journal:  J Org Chem       Date:  2009-04-17       Impact factor: 4.354

2.  A novel modifier of regulatory T cells.

Authors:  Naganari Ohkura; Shimon Sakaguchi
Journal:  Nat Immunol       Date:  2009-07       Impact factor: 25.606

3.  Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner.

Authors:  Sujoy Lahiri; Hyejung Park; Elad L Laviad; Xuequan Lu; Robert Bittman; Anthony H Futerman
Journal:  J Biol Chem       Date:  2009-04-08       Impact factor: 5.157

4.  A sphingosine-1 phosphate agonist (FTY720) limits trauma/hemorrhagic shock-induced multiple organ dysfunction syndrome.

Authors:  Joyce A Bonitz; Julie Y Son; Benjamin Chandler; Jacquelyn N Tomaio; Yong Qin; Lauriston M Prescott; Eleonora Feketeova; Edwin A Deitch
Journal:  Shock       Date:  2014-11       Impact factor: 3.454

5.  FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells.

Authors:  Evgeny V Berdyshev; Irina Gorshkova; Anastasia Skobeleva; Robert Bittman; Xuequan Lu; Steven M Dudek; Tamara Mirzapoiazova; Joe G N Garcia; Viswanathan Natarajan
Journal:  J Biol Chem       Date:  2009-01-01       Impact factor: 5.157

6.  Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration.

Authors:  Hui Chen; Julie-Thu A Tran; Annette Eckerd; Tuan-Phat Huynh; Michael H Elliott; Richard S Brush; Nawajes A Mandal
Journal:  J Lipid Res       Date:  2013-03-06       Impact factor: 5.922

7.  Prevention of CpG-induced pregnancy disruption by adoptive transfer of in vitro-induced regulatory T cells.

Authors:  Yi Lin; Xiaorui Liu; Bin Shan; Ji Wu; Surendra Sharma; Yun Sun
Journal:  PLoS One       Date:  2014-04-08       Impact factor: 3.240

8.  Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site.

Authors:  Kanchan Anand; Kenji Maeda; Anne-Claude Gavin
Journal:  PLoS One       Date:  2012-05-04       Impact factor: 3.240

9.  Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions.

Authors:  Peter Vogel; Michael S Donoviel; Robert Read; Gwenn M Hansen; Jill Hazlewood; Stephen J Anderson; Weimei Sun; Jonathan Swaffield; Tamas Oravecz
Journal:  PLoS One       Date:  2009-01-01       Impact factor: 3.240

10.  S1P1 receptor modulation preserves vascular function in mesenteric and coronary arteries after CPB in the rat independent of depletion of lymphocytes.

Authors:  Iryna V Samarska; Hjalmar R Bouma; Hendrik Buikema; Hubert E Mungroop; Martin C Houwertjes; Anthony R Absalom; Anne H Epema; Robert H Henning
Journal:  PLoS One       Date:  2014-05-12       Impact factor: 3.240
  10 in total

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