Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing.

Literature DB >> 19535464

The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing.

Ana Eulalio¹, Felix Tritschler, Elisa Izaurralde.

Abstract

GW182 family proteins interact directly with Argonaute proteins and are required for miRNA-mediated gene silencing in animal cells. The domains of the GW182 proteins have recently been studied to determine their role in silencing. These studies revealed that the middle and C-terminal regions function as an autonomous domain with a repressive function that is independent of both the interaction with Argonaute proteins and of P-body localization. Such findings reinforce the idea that GW182 proteins are key components of miRNA repressor complexes in metazoa.

Entities: Gene

Mesh：

Substances：

Year: 2009 PMID： 19535464 PMCID： PMC2714752 DOI： 10.1261/rna.1703809

Source DB: PubMed Journal: RNA ISSN： 1355-8382 Impact factor: 4.942

45 in total

1. A C-terminal silencing domain in GW182 is essential for miRNA function.

Authors: Ana Eulalio; Sigrun Helms; Christoph Fritzsch; Maria Fauser; Elisa Izaurralde
Journal: RNA Date: 2009-04-21 Impact factor: 4.942

2. A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles.

Authors: Theophany Eystathioy; Edward K L Chan; Scott A Tenenbaum; Jack D Keene; Kevin Griffith; Marvin J Fritzler
Journal: Mol Biol Cell Date: 2002-04 Impact factor: 4.138

3. The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.

Authors: Daniela Lazzaretti; Isabelle Tournier; Elisa Izaurralde
Journal: RNA Date: 2009-04-21 Impact factor: 4.942

4. Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway.

Authors: Keita Miyoshi; Tomoko N Okada; Haruhiko Siomi; Mikiko C Siomi
Journal: RNA Date: 2009-05-18 Impact factor: 4.942

5. Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression.

Authors: Koji Takimoto; Motoaki Wakiyama; Shigeyuki Yokoyama
Journal: RNA Date: 2009-04-27 Impact factor: 4.942

6. The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.

Authors: Shang L Lian; Songqing Li; Grant X Abadal; Brad A Pauley; Marvin J Fritzler; Edward K L Chan
Journal: RNA Date: 2009-03-26 Impact factor: 4.942

7. RNA-directed DNA methylation requires an AGO4-interacting member of the SPT5 elongation factor family.

Authors: Natacha Bies-Etheve; Dominique Pontier; Sylvie Lahmy; Claire Picart; Danielle Vega; Richard Cooke; Thierry Lagrange
Journal: EMBO Rep Date: 2009-04-03 Impact factor: 8.807

Review 8. From UBA to UBX: new words in the ubiquitin vocabulary.

Authors: Alexander Buchberger
Journal: Trends Cell Biol Date: 2002-05 Impact factor: 20.808

9. Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression.

Authors: Jakob T Zipprich; Sankar Bhattacharyya; Hansruedi Mathys; Witold Filipowicz
Journal: RNA Date: 2009-03-20 Impact factor: 4.942

10. The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing.

Authors: Ana Eulalio; Felix Tritschler; Regina Büttner; Oliver Weichenrieder; Elisa Izaurralde; Vincent Truffault
Journal: Nucleic Acids Res Date: 2009-03-18 Impact factor: 16.971

97 in total

Review 1. Local RNA translation at the synapse and in disease.

Authors: Liqun Liu-Yesucevitz; Gary J Bassell; Aaron D Gitler; Anne C Hart; Eric Klann; Joel D Richter; Stephen T Warren; Benjamin Wolozin
Journal: J Neurosci Date: 2011-11-09 Impact factor: 6.167

2. Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish.

Authors: Yuichiro Mishima; Akira Fukao; Tomoyoshi Kishimoto; Hiroshi Sakamoto; Toshinobu Fujiwara; Kunio Inoue
Journal: Proc Natl Acad Sci U S A Date: 2012-01-09 Impact factor: 11.205

3. miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT.

Authors: Marc R Fabian; Maja K Cieplak; Filipp Frank; Masahiro Morita; Jonathan Green; Tharan Srikumar; Bhushan Nagar; Tadashi Yamamoto; Brian Raught; Thomas F Duchaine; Nahum Sonenberg
Journal: Nat Struct Mol Biol Date: 2011-10-07 Impact factor: 15.369

The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing.

1. A C-terminal silencing domain in GW182 is essential for miRNA function.

2. A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles.

3. The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.

4. Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway.

5. Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression.

6. The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.

7. RNA-directed DNA methylation requires an AGO4-interacting member of the SPT5 elongation factor family.

Review 8. From UBA to UBX: new words in the ubiquitin vocabulary.

9. Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression.

10. The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing.

Review 1. Local RNA translation at the synapse and in disease.

2. Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish.

3. miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT.

Review 4. The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC.

Review 5. The widespread regulation of microRNA biogenesis, function and decay.

6. A viral suppressor protein inhibits host RNA silencing by hooking up with Argonautes.

Review 7. Mechanisms of translational regulation in synaptic plasticity.

Review 8. microRNAs in heart disease: putative novel therapeutic targets?

9. Mechanism of translational regulation by miR-2 from sites in the 5' untranslated region or the open reading frame.

10. TRIM65 regulates microRNA activity by ubiquitination of TNRC6.