Literature DB >> 19534505

Use of disulfide "staples" to stabilize beta-sheet quaternary structure.

Omid Khakshoor1, James S Nowick.   

Abstract

This Letter reports the use of disulfide linkages to stabilize a beta-sheet dimer with a well-defined structure in aqueous and dimethyl sulfoxide solutions. In this dimer, two cyclic beta-sheet peptides are connected by disulfide linkages at the non-hydrogen-bonded rings. The cyclic beta-sheet "domains" interact through hydrogen bonding to form a four-stranded beta-sheet structure. This interaction results in enhanced folding of the cyclic beta-sheet peptides.

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Year:  2009        PMID： 19534505      PMCID： PMC2726807          DOI： 10.1021/ol901015a

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  11 in total

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Authors:  James S Nowick
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2.  beta-sheet hydrogen bonding patterns in cystine peptides.

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3.  Exploring beta-sheet structure and interactions with chemical model systems.

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Review 4.  Chemical shifts as a tool for structure determination.

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Review 5.  Disulfide bonds and protein folding.

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Journal:  Biochemistry       Date:  2000-04-18       Impact factor: 3.162

6.  A new turn structure for the formation of beta-hairpins in peptides.

Authors:  James S Nowick; Justin O Brower
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7.  Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.

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Journal:  Science       Date:  2004-09-03       Impact factor: 47.728

8.  Context-dependence of the contribution of disulfide bonds to beta-hairpin stability.

Authors:  Clara M Santiveri; Esther León; Manuel Rico; M Angeles Jiménez
Journal:  Chemistry       Date:  2008       Impact factor: 5.236

Review 9.  Protein disulfide bond formation in prokaryotes.

Authors:  Hiroshi Kadokura; Federico Katzen; Jon Beckwith
Journal:  Annu Rev Biochem       Date:  2003-01-09       Impact factor: 23.643

10.  Macrocyclic beta-sheet peptides that mimic protein quaternary structure through intermolecular beta-sheet interactions.

Authors:  Omid Khakshoor; Borries Demeler; James S Nowick
Journal:  J Am Chem Soc       Date:  2007-04-10       Impact factor: 15.419
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  13 in total

1.  Controlling the Oligomerization State of Aβ-Derived Peptides with Light.

Authors:  Patrick J Salveson; Sepehr Haerianardakani; Alexander Thuy-Boun; Adam G Kreutzer; James S Nowick
Journal:  J Am Chem Soc       Date:  2018-04-20       Impact factor: 15.419

Review 2.  The supramolecular chemistry of β-sheets.

Authors:  Pin-Nan Cheng; Johnny D Pham; James S Nowick
Journal:  J Am Chem Soc       Date:  2013-04-02       Impact factor: 15.419

3.  Disulfide Connectivity Analysis of Peptides Bearing Two Intramolecular Disulfide Bonds Using MALDI In-Source Decay.

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4.  Convergent diversity-oriented side-chain macrocyclization scan for unprotected polypeptides.

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Journal:  Org Biomol Chem       Date:  2014-01-28       Impact factor: 3.876

5.  Giant macrolactams based on β-sheet peptides.

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Journal:  J Org Chem       Date:  2011-04-15       Impact factor: 4.354

6.  Cyclic N-terminal loop of amylin forms non amyloid fibers.

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7.  X-ray crystallographic structure of an artificial beta-sheet dimer.

Authors:  Omid Khakshoor; Aaron J Lin; Tyler P Korman; Michael R Sawaya; Shiou-Chuan Tsai; David Eisenberg; James S Nowick
Journal:  J Am Chem Soc       Date:  2010-08-25       Impact factor: 15.419

8.  Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors.

Authors:  S Munir Alam; S Moses Dennison; Baptiste Aussedat; Yusuf Vohra; Peter K Park; Alberto Fernández-Tejada; Shelley Stewart; Frederick H Jaeger; Kara Anasti; Julie H Blinn; Thomas B Kepler; Mattia Bonsignori; Hua-Xin Liao; Joseph G Sodroski; Samuel J Danishefsky; Barton F Haynes
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-21       Impact factor: 11.205

9.  Macrocyclic β-sheet peptides that inhibit the aggregation of a tau-protein-derived hexapeptide.

Authors:  Jing Zheng; Cong Liu; Michael R Sawaya; Balraju Vadla; Shafiullah Khan; R Jeremy Woods; David Eisenberg; Warren J Goux; James S Nowick
Journal:  J Am Chem Soc       Date:  2011-02-14       Impact factor: 15.419

Review 10.  Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.

Authors:  Marta Pelay-Gimeno; Adrian Glas; Oliver Koch; Tom N Grossmann
Journal:  Angew Chem Int Ed Engl       Date:  2015-06-26       Impact factor: 15.336
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