Literature DB >> 19533719

Bipartite tetracysteine display requires site flexibility for ReAsH coordination.

Jessica L Goodman1, Daniel B Fried, Alanna Schepartz.   

Abstract

Flexibility required: We designed intramolecular bipartite tetracysteine sites in loops of p53 and the beta-sheets of EmGFP. We found that ReAsH binding preferentially favors tetracysteine sites with flexible geometries such as loops; flexibility was assessed by comparing Calpha B-factor values. This information is important for directing successful bipartite tetracysteine site designs.

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Year:  2009        PMID： 19533719      PMCID： PMC2773557          DOI： 10.1002/cbic.200900207

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  16 in total

1.  p53 contains large unstructured regions in its native state.

Authors:  Stefan Bell; Christian Klein; Lin Müller; Silke Hansen; Johannes Buchner
Journal:  J Mol Biol       Date:  2002-10-04       Impact factor: 5.469

2.  Prediction of protein B-factor profiles.

Authors:  Zheng Yuan; Timothy L Bailey; Rohan D Teasdale
Journal:  Proteins       Date:  2005-03-01

3.  Specific covalent labeling of recombinant protein molecules inside live cells.

Authors:  B A Griffin; S R Adams; R Y Tsien
Journal:  Science       Date:  1998-07-10       Impact factor: 47.728

Review 4.  p53, the cellular gatekeeper for growth and division.

Authors:  A J Levine
Journal:  Cell       Date:  1997-02-07       Impact factor: 41.582

Review 5.  The p53 tumour suppressor gene.

Authors:  A J Levine; J Momand; C A Finlay
Journal:  Nature       Date:  1991-06-06       Impact factor: 49.962

6.  Crystal structure of the Aequorea victoria green fluorescent protein.

Authors:  M Ormö; A B Cubitt; K Kallio; L A Gross; R Y Tsien; S J Remington
Journal:  Science       Date:  1996-09-06       Impact factor: 47.728

7.  New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications.

Authors:  Stephen R Adams; Robert E Campbell; Larry A Gross; Brent R Martin; Grant K Walkup; Yong Yao; Juan Llopis; Roger Y Tsien
Journal:  J Am Chem Soc       Date:  2002-05-29       Impact factor: 15.419

8.  Ligand binding and structural analysis of a human putative cellular retinol-binding protein.

Authors:  Claudia Folli; Vito Calderone; Ileana Ramazzina; Giuseppe Zanotti; Rodolfo Berni
Journal:  J Biol Chem       Date:  2002-08-09       Impact factor: 5.157

9.  Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations.

Authors:  Y Cho; S Gorina; P D Jeffrey; N P Pavletich
Journal:  Science       Date:  1994-07-15       Impact factor: 47.728

10.  Cross-strand split tetra-Cys motifs as structure sensors in a beta-sheet protein.

Authors:  Beena Krishnan; Lila M Gierasch
Journal:  Chem Biol       Date:  2008-10-20
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  13 in total

1.  Bipartite tetracysteine display reveals allosteric control of ligand-specific EGFR activation.

Authors:  Rebecca A Scheck; Melissa A Lowder; Jacob S Appelbaum; Alanna Schepartz
Journal:  ACS Chem Biol       Date:  2012-06-05       Impact factor: 5.100

2.  Effects of FlAsH/tetracysteine (TC) Tag on PrP proteolysis and PrPres formation by TC-scanning.

Authors:  Yuzuru Taguchi; Lindsay A Hohsfield; Jason R Hollister; Gerald S Baron
Journal:  Chembiochem       Date:  2013-08-13       Impact factor: 3.164

3.  Rotamer-Restricted Fluorogenicity of the Bis-Arsenical ReAsH.

Authors:  Allison S Walker; Paul R Rablen; Alanna Schepartz
Journal:  J Am Chem Soc       Date:  2016-05-10       Impact factor: 15.419

Review 4.  Advances in chemical labeling of proteins in living cells.

Authors:  Qi Yan; Marcel P Bruchez
Journal:  Cell Tissue Res       Date:  2015-03-07       Impact factor: 5.249

5.  Surveying protein structure and function using bis-arsenical small molecules.

Authors:  Rebecca A Scheck; Alanna Schepartz
Journal:  Acc Chem Res       Date:  2011-07-18       Impact factor: 22.384

Review 6.  Visualizing protein partnerships in living cells and organisms.

Authors:  Melissa A Lowder; Jacob S Appelbaum; Elissa M Hobert; Alanna Schepartz
Journal:  Curr Opin Chem Biol       Date:  2011-11-19       Impact factor: 8.822

7.  Visualizing tyrosine kinase activity with bipartite tetracysteine display.

Authors:  Sarmistha Ray-Saha; Alanna Schepartz
Journal:  Chembiochem       Date:  2010-10-18       Impact factor: 3.164

8.  Direct visualization of protein association in living cells with complex-edited electron microscopy.

Authors:  Rachel J Dexter; Alanna Schepartz
Journal:  Angew Chem Int Ed Engl       Date:  2010-10-18       Impact factor: 15.336

9.  A sensitive assay reveals structural requirements for α-synuclein fibril growth.

Authors:  Dhruva D Dhavale; Christina Tsai; Devika P Bagchi; Laura A Engel; Jonathan Sarezky; Paul T Kotzbauer
Journal:  J Biol Chem       Date:  2017-04-03       Impact factor: 5.157

10.  FACS-based selection of tandem tetracysteine peptides with improved ReAsH brightness in live cells.

Authors:  Schuyler B Van Engelenburg; Theresa Nahreini; Amy E Palmer
Journal:  Chembiochem       Date:  2010-03-01       Impact factor: 3.164
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