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Literature DB >> 22902070

p62 Stages an interplay between the ubiquitin-proteasome system and autophagy in the heart of defense against proteotoxic stress.

Abstract

As exemplified by desmin-related cardiomyopathy and myocardial ischemia/reperfusion injury, proteasome functional insufficiency plays an essential pathogenic role in the progression of cardiac diseases with elevated proteotoxic stress. Upregulation of p62/SQSTM1 and increased selective autophagy in cardiomyocytes may protect against proteotoxic stress in the heart. p62 may serve as a proteotoxic stress sensor, promote segregation and degradation of misfolded proteins by autophagy, and mediate the cross talk between the ubiquitin-proteasome system and autophagy.

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Year: 2011 PMID： 22902070 PMCID： PMC3424486 DOI： 10.1016/j.tcm.2012.05.015

Source DB: PubMed Journal: Trends Cardiovasc Med ISSN： 1050-1738 Impact factor: 6.677

39 in total

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