Literature DB >> 19522828

Parafibromin--functional insights.

P J Newey1, M R Bowl, R V Thakker.   

Abstract

Parafibromin is a predominantly nuclear protein with a tumour suppressor role in the development of hereditary and nonhereditary parathyroid carcinomas, and the hyperparathyroidism-jaw tumour syndrome, which is associated with renal and uterine tumours. Parafibromin is a component of the highly conserved PAF1 complex, which regulates transcriptional events and histone modifications. The parafibromin/PAF1 complex regulates genes involved in cell growth and survival, and via these, parafibromin plays a pivotal role in embryonic development and survival of adults.

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Year:  2009        PMID： 19522828     DOI： 10.1111/j.1365-2796.2009.02107.x

Source DB:  PubMed          Journal:  J Intern Med        ISSN： 0954-6820            Impact factor:   8.989


  33 in total

1.  Cdc73 subunit of Paf1 complex contains C-terminal Ras-like domain that promotes association of Paf1 complex with chromatin.

Authors:  Christopher G Amrich; Christopher P Davis; Walter P Rogal; Margaret K Shirra; Annie Heroux; Richard G Gardner; Karen M Arndt; Andrew P VanDemark
Journal:  J Biol Chem       Date:  2012-02-08       Impact factor: 5.157

Review 2.  Imaging for Screening and Surveillance of Patients with Hereditary Forms of Renal Cell Carcinoma.

Authors:  Yuval Freifeld; Lakshmi Ananthakrishnan; Vitaly Margulis
Journal:  Curr Urol Rep       Date:  2018-08-16       Impact factor: 3.092

3.  Novel nonsense CDC73 mutations in Chinese patients with parathyroid tumors.

Authors:  Wai Kwan Siu; Chun Yiu Law; Ching Wan Lam; Chloe Miu Mak; Gary Wing Kin Wong; Andrew Yiu Yan Ho; Kwok Yip Ho; Ka Tai Loo; Sin Chuen Chiu; Louis Tsun Cheung Chow; Sui Fan Tong; Albert Yan Wo Chan
Journal:  Fam Cancer       Date:  2011-12       Impact factor: 2.375

4.  The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis.

Authors:  Andrew G Muntean; Jiaying Tan; Kajal Sitwala; Yongsheng Huang; Joel Bronstein; James A Connelly; Venkatesha Basrur; Kojo S J Elenitoba-Johnson; Jay L Hess
Journal:  Cancer Cell       Date:  2010-06-15       Impact factor: 31.743

Review 5.  Emerging Insights into the Roles of the Paf1 Complex in Gene Regulation.

Authors:  S Branden Van Oss; Christine E Cucinotta; Karen M Arndt
Journal:  Trends Biochem Sci       Date:  2017-09-01       Impact factor: 13.807

Review 6.  Genetics of Hyperparathyroidism, Including Parathyroid Cancer.

Authors:  William F Simonds
Journal:  Endocrinol Metab Clin North Am       Date:  2017-02-23       Impact factor: 4.741

Review 7.  Primary hyperparathyroidism.

Authors:  John P Bilezikian; Natalie E Cusano; Aliya A Khan; Jian-Min Liu; Claudio Marcocci; Francisco Bandeira
Journal:  Nat Rev Dis Primers       Date:  2016-05-19       Impact factor: 52.329

Review 8.  Endocrine neoplasms in familial syndromes of hyperparathyroidism.

Authors:  Yulong Li; William F Simonds
Journal:  Endocr Relat Cancer       Date:  2016-05-20       Impact factor: 5.678

9.  The roles of parafibromin expression in ovarian epithelial carcinomas: a marker for differentiation and prognosis and a target for gene therapy.

Authors:  Dao-Fu Shen; Xin Liu; Xue-Feng Yang; Lei Fang; Yang Gao; Shuang Zhao; Ji-Cheng Wu; Shuai Shi; Jun-Jun Li; Xiang-Xuan Zhao; Wen-Feng Gou; Hua-Chuan Zheng
Journal:  Tumour Biol       Date:  2015-09-26

10.  The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states.

Authors:  Brett N Tomson; Karen M Arndt
Journal:  Biochim Biophys Acta       Date:  2012-09-06
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