Literature DB >> 19519409

Mechanisms of protein aggregation.

John S Philo1, Tsutomu Arakawa.   

Abstract

Aggregation or reversible self-association of protein therapeutics can arise through a number of different mechanisms. Five common aggregation mechanisms are described and their relations to manufacturing processes to suppress and remove aggregates are discussed.

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Year:  2009        PMID： 19519409     DOI： 10.2174/138920109788488932

Source DB:  PubMed          Journal:  Curr Pharm Biotechnol        ISSN： 1389-2010            Impact factor:   2.837


  46 in total

1.  Structure of the signal transduction protein TRAP (target of RNAIII-activating protein).

Authors:  Kim Henrick; Miriam Hirshberg
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2012-06-22

2.  Radar chart array analysis to visualize effects of formulation variables on IgG1 particle formation as measured by multiple analytical techniques.

Authors:  Cavan Kalonia; Ozan S Kumru; Jae Hyun Kim; C Russell Middaugh; David B Volkin
Journal:  J Pharm Sci       Date:  2013-10-09       Impact factor: 3.534

3.  O-linked glycosylation leads to decreased thermal stability of interferon alpha 2b as measured by two orthogonal techniques.

Authors:  Michael James Wilson Johnston; Grant Frahm; Xuguang Li; Yves Durocher; Mary Alice Hefford
Journal:  Pharm Res       Date:  2011-03-09       Impact factor: 4.200

Review 4.  Stability of protein pharmaceuticals: an update.

Authors:  Mark Cornell Manning; Danny K Chou; Brian M Murphy; Robert W Payne; Derrick S Katayama
Journal:  Pharm Res       Date:  2010-02-09       Impact factor: 4.200

5.  Protein structural dynamics at the gas/water interface examined by hydrogen exchange mass spectrometry.

Authors:  Yiming Xiao; Lars Konermann
Journal:  Protein Sci       Date:  2015-04-02       Impact factor: 6.725

6.  Energetic Dissection of Mab-Specific Reversible Self-Association Reveals Unique Thermodynamic Signatures.

Authors:  Mandi M Hopkins; Arun Parupudi; Jared S Bee; David L Bain
Journal:  Pharm Res       Date:  2021-02-18       Impact factor: 4.200

7.  A Multiparticulate Delivery System for Potential Colonic Targeting Using Bovine Serum Albumin as a Model Protein : Theme: Formulation and Manufacturing of Solid Dosage Forms Guest Editors: Tony Zhou and Tonglei Li.

Authors:  Bowen Jiang; Hua Yu; Yongrong Zhang; Hanping Feng; Stephen W Hoag
Journal:  Pharm Res       Date:  2017-08-14       Impact factor: 4.200

8.  Metal ions guided self-assembly of therapeutic proteins for controllable release: from random to ordered aggregation.

Authors:  Kai Shi; Fude Cui; Hongshu Bi; Yanbo Jiang; Hang Shi; Tao Song
Journal:  Pharm Res       Date:  2012-09-14       Impact factor: 4.200

9.  Protein instability following transport or storage on dry ice.

Authors:  Brian M Murphy; Spencer Swarts; Barbara M Mueller; Peter van der Geer; Mark C Manning; Mark I Fitchmun
Journal:  Nat Methods       Date:  2013-04       Impact factor: 28.547

10.  Computational modeling of the relationship between amyloid and disease.

Authors:  Damien Hall; Herman Edskes
Journal:  Biophys Rev       Date:  2012-09
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