Literature DB >> 19506575

Challenges of translating genetic tests into clinical and public health practice.

Wolf H Rogowski1, Scott D Grosse, Muin J Khoury.   

Abstract

Research in genetics and genomics has led to an expanding list of molecular genetic tests, which are increasingly entering health care systems. However, the evidence surrounding the benefits and harms of these tests is frequently weak. Here we present the main challenges to the successful translation of new research findings about genotype-phenotype associations into clinical practice. We discuss the means to achieve an accelerated translation research agenda that is conducted in a reasonable, fair and efficient manner.

Mesh:

Year:  2009        PMID: 19506575     DOI: 10.1038/nrg2606

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN: 1471-0056            Impact factor:   53.242


  51 in total

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Review 2.  Priority setting for health technology assessments: a systematic review of current practical approaches.

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3.  Coverage with evidence development: an examination of conceptual and policy issues.

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Review 4.  Economic methods for valuing the outcomes of genetic testing: beyond cost-effectiveness analysis.

Authors:  Scott D Grosse; Sarah Wordsworth; Katherine Payne
Journal:  Genet Med       Date:  2008-09       Impact factor: 8.822

5.  Aversion to health inequalities and priority setting in health care.

Authors:  Han Bleichrodt; David Crainich; Louis Eeckhoudt
Journal:  J Health Econ       Date:  2008-07-23       Impact factor: 3.883

6.  IFCC position paper: report of the IFCC taskforce on ethics: introduction and framework.

Authors:  Leslie Burnett; Matthew J McQueen; Jon Johannes Jonsson; Francesca Torricelli
Journal:  Clin Chem Lab Med       Date:  2007       Impact factor: 3.694

Review 7.  Cost-minimization analysis of genetic testing versus clinical screening of at-risk relatives for familial adenomatous polyposis.

Authors:  Yamina Chikhaoui; Huguette Gélinas; Lawrence Joseph; Jean-Marie Lance
Journal:  Int J Technol Assess Health Care       Date:  2002       Impact factor: 2.188

8.  Retinoblastoma: genetic testing versus conventional clinical screening in India.

Authors:  Biju Joseph; Mahesh Palanivelu Shanmugam; Madhuravasal Krishnan Srinivasan; Govindasamy Kumaramanickavel
Journal:  Mol Diagn       Date:  2004

Review 9.  Pharmacoeconomic evaluations of pharmacogenetic and genomic screening programmes: a systematic review on content and adherence to guidelines.

Authors:  Stefan Vegter; Cornelis Boersma; Mark Rozenbaum; Bob Wilffert; Gerjan Navis; Maarten J Postma
Journal:  Pharmacoeconomics       Date:  2008       Impact factor: 4.981

10.  Prioritizing future research on off-label prescribing: results of a quantitative evaluation.

Authors:  Surrey M Walton; Glen T Schumock; Ky-Van Lee; G Caleb Alexander; David Meltzer; Randall S Stafford
Journal:  Pharmacotherapy       Date:  2008-12       Impact factor: 4.705

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  43 in total

1.  Points to consider in assessing and appraising predictive genetic tests.

Authors:  Wolf H Rogowski; Scott D Grosse; Jürgen John; Helena Kääriäinen; Alastair Kent; Ulf Kristofferson; Jörg Schmidtke
Journal:  J Community Genet       Date:  2010-10-16

2.  Criteria for fairly allocating scarce health-care resources to genetic tests: which matter most?

Authors:  Wolf H Rogowski; Scott D Grosse; Jörg Schmidtke; Georg Marckmann
Journal:  Eur J Hum Genet       Date:  2013-08-07       Impact factor: 4.246

Review 3.  Genetic testing and common disorders in a public health framework: how to assess relevance and possibilities. Background Document to the ESHG recommendations on genetic testing and common disorders.

Authors:  Frauke Becker; Carla G van El; Dolores Ibarreta; Eleni Zika; Stuart Hogarth; Pascal Borry; Anne Cambon-Thomsen; Jean Jacques Cassiman; Gerry Evers-Kiebooms; Shirley Hodgson; A Cécile J W Janssens; Helena Kaariainen; Michael Krawczak; Ulf Kristoffersson; Jan Lubinski; Christine Patch; Victor B Penchaszadeh; Andrew Read; Wolf Rogowski; Jorge Sequeiros; Lisbeth Tranebjaerg; Irene M van Langen; Helen Wallace; Ron Zimmern; Jörg Schmidtke; Martina C Cornel
Journal:  Eur J Hum Genet       Date:  2011-04       Impact factor: 4.246

4.  Integrating genetic studies of nicotine addiction into public health practice: stakeholder views on challenges, barriers and opportunities.

Authors:  M J Dingel; A D Hicks; M E Robinson; B A Koenig
Journal:  Public Health Genomics       Date:  2011-07-09       Impact factor: 2.000

5.  Genomic analysis in the clinic: benefits and challenges for health care professionals and patients in Brazil.

Authors:  Patrícia Ashton-Prolla; José Roberto Goldim; Filippo Pinto E Vairo; Ursula da Silveira Matte; Jorge Sequeiros
Journal:  J Community Genet       Date:  2015-06-04

Review 6.  Addressing multimorbidity in evidence integration and synthesis.

Authors:  Thomas A Trikalinos; Jodi B Segal; Cynthia M Boyd
Journal:  J Gen Intern Med       Date:  2014-01-18       Impact factor: 5.128

Review 7.  Rare inherited kidney diseases: challenges, opportunities, and perspectives.

Authors:  Olivier Devuyst; Nine V A M Knoers; Giuseppe Remuzzi; Franz Schaefer
Journal:  Lancet       Date:  2014-05-24       Impact factor: 79.321

8.  Valuations of genetic test information for treatable conditions: the case of colorectal cancer screening.

Authors:  Vikram Kilambi; F Reed Johnson; Juan Marcos González; Ateesha F Mohamed
Journal:  Value Health       Date:  2014-11-06       Impact factor: 5.725

9.  Personalized medicine and genomics: challenges and opportunities in assessing effectiveness, cost-effectiveness, and future research priorities.

Authors:  Rena Conti; David L Veenstra; Katrina Armstrong; Lawrence J Lesko; Scott D Grosse
Journal:  Med Decis Making       Date:  2010-01-04       Impact factor: 2.583

10.  Eliciting preferences for priority setting in genetic testing: a pilot study comparing best-worst scaling and discrete-choice experiments.

Authors:  Franziska Severin; Jörg Schmidtke; Axel Mühlbacher; Wolf H Rogowski
Journal:  Eur J Hum Genet       Date:  2013-03-13       Impact factor: 4.246

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