Literature DB >> 19492388

Monoclonal antibodies with orthogonal azaspiracid epitopes.

Michael O Frederick1, Sandra De Lamo Marin, Kim D Janda, K C Nicolaou, Tobin J Dickerson.   

Abstract

Azaspiracid antibodies: Immunization of azaspiracid immunoconjugates has elicited monoclonal antibodies with distinct epitopes on the marine toxin; this will open the way toward azaspiracid diagnostics and the detection of contaminated shellfish before they can enter the food supply.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19492388      PMCID： PMC2750835          DOI： 10.1002/cbic.200900201

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  28 in total

1.  Synthesis of the FGHI Ring System of Azaspiracid We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from Bristol-Myers Squibb (F.B.), postdoctoral fellowships from the Academy of Finland, the Ella and Georg Ehrnrooth Foundation, and the Tauno Tönning Foundation (all to P.M.P.), ArrayBiopharma (N.Z.), and Bayer AG (N.D.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.

Authors:  K. C. Nicolaou; Petri M. Pihko; Nicole Diedrichs; Ning Zou; Federico Bernal
Journal:  Angew Chem Int Ed Engl       Date:  2001-04-01       Impact factor: 15.336

2.  Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland.

Authors:  E Ito; M Satake; K Ofuji; N Kurita; T McMahon; K James; T Yasumoto
Journal:  Toxicon       Date:  2000-07       Impact factor: 3.033

3.  Determination of azaspiracids in shellfish using liquid chromatography/tandem electrospray mass spectrometry.

Authors:  Ambrose Furey; Ana Braña-Magdalena; Mary Lehane; Cian Moroney; Kevin J James; Masayuki Satake; Takeshi Yasumoto
Journal:  Rapid Commun Mass Spectrom       Date:  2002       Impact factor: 2.419

4.  Two analogs of azaspiracid isolated from mussels, Mytilus edulis, involved in human intoxication in Ireland.

Authors:  K Ofuji; M Satake; T McMahon; J Silke; K J James; H Naoki; Y Oshima; T Yasumoto
Journal:  Nat Toxins       Date:  1999

5.  Development of a method for the identification of azaspiracid in shellfish by liquid chromatography-tandem mass spectrometry.

Authors:  R Draisci; L Palleschi; E Ferretti; A Furey; K J James; M Satake; T Yasumoto
Journal:  J Chromatogr A       Date:  2000-02-25       Impact factor: 4.759

6.  Chronic effects in mice caused by oral administration of sublethal doses of azaspiracid, a new marine toxin isolated from mussels.

Authors:  Emiko Ito; Masayuki Satake; Katsuya Ofuji; Morihiro Higashi; Kenichi Harigaya; Terry McMahon; Takeshi Yasumoto
Journal:  Toxicon       Date:  2002-02       Impact factor: 3.033

7.  A cytotoxicity assay for the detection and differentiation of two families of shellfish toxins.

Authors:  A F Flanagan; K R Callanan; J Donlon; R Palmer; A Forde; M Kane
Journal:  Toxicon       Date:  2001-07       Impact factor: 3.033

8.  Liquid chromatography with electrospray ion trap mass spectrometry for the determination of five azaspiracids in shellfish.

Authors:  M Lehane; A Braña-Magdalena; C Moroney; A Furey; K J James
Journal:  J Chromatogr A       Date:  2002-03-15       Impact factor: 4.759

9.  Azaspiracid shellfish poisoning: unusual toxin dynamics in shellfish and the increased risk of acute human intoxications.

Authors:  K J James; M Lehane; C Moroney; P Fernandez-Puente; M Satake; T Yasumoto; A Furey
Journal:  Food Addit Contam       Date:  2002-06

10.  Structures of azaspiracid analogs, azaspiracid-4 and azaspiracid-5, causative toxins of azaspiracid poisoning in Europe.

Authors:  K Ofuji; M Satake; T Mcmahon; K J James; H Naoki; Y Oshima; T Yasumoto
Journal:  Biosci Biotechnol Biochem       Date:  2001-03       Impact factor: 2.043
View more
  5 in total

Review 1.  Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.

Authors:  K C Nicolaou; Christopher R H Hale; Christian Nilewski; Heraklidia A Ioannidou
Journal:  Chem Soc Rev       Date:  2012-06-28       Impact factor: 54.564

2.  Microsphere-based immunoassay for the detection of azaspiracids.

Authors:  Laura P Rodríguez; Natalia Vilariño; M Carmen Louzao; Tobin J Dickerson; K C Nicolaou; Michael O Frederick; Luis M Botana
Journal:  Anal Biochem       Date:  2013-11-08       Impact factor: 3.365

Review 3.  Current Trends and New Challenges in Marine Phycotoxins.

Authors:  Maria Carmen Louzao; Natalia Vilariño; Carmen Vale; Celia Costas; Alejandro Cao; Sandra Raposo-Garcia; Mercedes R Vieytes; Luis M Botana
Journal:  Mar Drugs       Date:  2022-03-08       Impact factor: 5.118

4.  Use of biosensors as alternatives to current regulatory methods for marine biotoxins.

Authors:  Natalia Vilariño; Eva S Fonfría; M Carmen Louzao; Luis M Botana
Journal:  Sensors (Basel)       Date:  2009-11-24       Impact factor: 3.576

Review 5.  Emerging Marine Biotoxins in European Waters: Potential Risks and Analytical Challenges.

Authors:  Paz Otero; Marisa Silva
Journal:  Mar Drugs       Date:  2022-03-08       Impact factor: 5.118
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.