Literature DB >> 11330704

Structures of azaspiracid analogs, azaspiracid-4 and azaspiracid-5, causative toxins of azaspiracid poisoning in Europe.

K Ofuji1, M Satake, T Mcmahon, K J James, H Naoki, Y Oshima, T Yasumoto.   

Abstract

Two new analogs of azaspiracid, azaspiracid-4 and azaspiracid-5, isolated from the mussel Mytilus edulis, involved in a newly emerged shellfish poisoning in Europe were determined to be 3-hydroxy-22-demethylazaspiracid and 23-hydroxy-22-demethylazaspiracid, respectively.

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Year:  2001        PMID： 11330704     DOI： 10.1271/bbb.65.740

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  17 in total

Review 1.  Algal biotoxins of marine origin: new indications from the European Union.

Authors:  R Poletti; A Milandri; M Pompei
Journal:  Vet Res Commun       Date:  2003-09       Impact factor: 2.459

2.  Monoclonal antibodies with orthogonal azaspiracid epitopes.

Authors:  Michael O Frederick; Sandra De Lamo Marin; Kim D Janda; K C Nicolaou; Tobin J Dickerson
Journal:  Chembiochem       Date:  2009-07-06       Impact factor: 3.164

3.  Subacute Cardiovascular Toxicity of the Marine Phycotoxin Azaspiracid-1 in Rats.

Authors:  Sara F Ferreiro; Natalia Vilariño; Cristina Carrera; M Carmen Louzao; Antonio G Cantalapiedra; Germán Santamarina; J Manuel Cifuentes; Andrés C Vieira; Luis M Botana
Journal:  Toxicol Sci       Date:  2016-02-10       Impact factor: 4.849

Review 4.  Impact of marine drugs on cytoskeleton-mediated reproductive events.

Authors:  Francesco Silvestre; Elisabetta Tosti
Journal:  Mar Drugs       Date:  2010-03-25       Impact factor: 5.118

5.  Azaspiracid substituent at C1 is relevant to in vitro toxicity.

Authors:  Natalia Vilariño; K C Nicolaou; Michael O Frederick; Eva Cagide; Carmen Alfonso; Eva Alonso; Mercedes R Vieytes; Luis M Botana
Journal:  Chem Res Toxicol       Date:  2008-08-16       Impact factor: 3.739

6.  Synthesis of the ABC ring system of Azaspiracid. 2. A systematic study into the effect of C(16) and C(17) substitution on bis-spirocyclization.

Authors:  Rich G Carter; David E Graves; Melissa A Gronemeyer; Gregory S Tschumper
Journal:  Org Lett       Date:  2002-06-27       Impact factor: 6.005

7.  Synthesis of the ABC ring system of azaspiracid. 1. Effect of D ring truncation on bis-spirocyclization.

Authors:  Rich G Carter; T Campbell Bourland; David E Graves
Journal:  Org Lett       Date:  2002-06-27       Impact factor: 6.005

8.  Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-Jun-N-terminal kinase activation in cultured neurons.

Authors:  Carmen Vale; Kyriacos C Nicolaou; Michael O Frederick; Mercedes R Vieytes; Luis M Botana
Journal:  Toxicol Sci       Date:  2009-10-08       Impact factor: 4.849

9.  Involvement of caspase activation in azaspiracid-induced neurotoxicity in neocortical neurons.

Authors:  Zhengyu Cao; Keith T LePage; Michael O Frederick; Kyriacos C Nicolaou; Thomas F Murray
Journal:  Toxicol Sci       Date:  2010-01-04       Impact factor: 4.849

10.  Total synthesis of (+)-azaspiracid-1. An exhibition of the intricacies of complex molecule synthesis.

Authors:  David A Evans; Lisbet Kvaernø; Travis B Dunn; André Beauchemin; Brian Raymer; Jason A Mulder; Edward J Olhava; Martin Juhl; Katsuji Kagechika; David A Favor
Journal:  J Am Chem Soc       Date:  2008-12-03       Impact factor: 15.419
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