BACKGROUND: Subtle abnormalities in frontal white matter have been reported in bipolar disorder. AIMS: To assess whether impaired integrity of white matter tracts is associated with bipolar disorder and genetic liability for the disorder. METHOD: A total of 19 patients with psychotic bipolar I disorder from multiply affected families, 21 unaffected first-degree relatives and 18 comparison individuals (controls) underwent diffusion tensor imaging. Whole brain voxel-based analyses compared fractional anisotropy between patients and relatives with controls, and its relationship with a quantitative measure of genetic liability. RESULTS: Patients had decreased fractional anisotropy compared with controls in the genu of the corpus callosum, right inferior longitudinal fasciculus and left superior longitudinal fasciculus. Increased genetic liability for bipolar disorder was associated with reduced fractional anisotropy across distributed regions of white matter in patients and their unaffected relatives. CONCLUSIONS: Disturbed structural integrity within key intra- and interhemispheric tracts characterises both bipolar disorder and genetic liability for this illness.
BACKGROUND:Subtle abnormalities in frontal white matter have been reported in bipolar disorder. AIMS: To assess whether impaired integrity of white matter tracts is associated with bipolar disorder and genetic liability for the disorder. METHOD: A total of 19 patients with psychotic bipolar I disorder from multiply affected families, 21 unaffected first-degree relatives and 18 comparison individuals (controls) underwent diffusion tensor imaging. Whole brain voxel-based analyses compared fractional anisotropy between patients and relatives with controls, and its relationship with a quantitative measure of genetic liability. RESULTS:Patients had decreased fractional anisotropy compared with controls in the genu of the corpus callosum, right inferior longitudinal fasciculus and left superior longitudinal fasciculus. Increased genetic liability for bipolar disorder was associated with reduced fractional anisotropy across distributed regions of white matter in patients and their unaffected relatives. CONCLUSIONS: Disturbed structural integrity within key intra- and interhemispheric tracts characterises both bipolar disorder and genetic liability for this illness.
Authors: Amelia Versace; Cecile D Ladouceur; Soledad Romero; Boris Birmaher; David A Axelson; David J Kupfer; Mary L Phillips Journal: J Am Acad Child Adolesc Psychiatry Date: 2010-10-29 Impact factor: 8.829
Authors: A Versace; C D Ladouceur; S Graur; H E Acuff; L K Bonar; K Monk; A McCaffrey; A Yendiki; A Leemans; M J Travis; V A Diwadkar; S K Holland; J L Sunshine; R A Kowatch; S M Horwitz; T W Frazier; L E Arnold; M A Fristad; E A Youngstrom; R L Findling; B I Goldstein; T Goldstein; D Axelson; B Birmaher; M L Phillips Journal: Neuropsychopharmacology Date: 2018-05-04 Impact factor: 7.853
Authors: Heather C Whalley; Emma Sprooten; Suzanna Hackett; Lynsey Hall; Douglas H Blackwood; David C Glahn; Mark Bastin; Jeremy Hall; Stephen M Lawrie; Jessika E Sussmann; Andrew M McIntosh Journal: Biol Psychiatry Date: 2013-02-28 Impact factor: 13.382
Authors: Emma Sprooten; Jennifer Barrett; D Reese McKay; Emma E Knowles; Samuel R Mathias; Anderson M Winkler; Margaret S Brumbaugh; Stefanie Landau; Lindsay Cyr; Peter Kochunov; David C Glahn Journal: Hum Brain Mapp Date: 2016-05-16 Impact factor: 5.038