| Literature DB >> 19475667 |
Sonja W Scholz1, Henry Houlden, Claudia Schulte, Manu Sharma, Abi Li, Daniela Berg, Anna Melchers, Reema Paudel, J Raphael Gibbs, Javier Simon-Sanchez, Coro Paisan-Ruiz, Jose Bras, Jinhui Ding, Honglei Chen, Bryan J Traynor, Sampath Arepalli, Ryan R Zonozi, Tamas Revesz, Janice Holton, Nick Wood, Andrew Lees, Wolfgang Oertel, Ullrich Wüllner, Stefano Goldwurm, Maria Teresa Pellecchia, Thomas Illig, Olaf Riess, Hubert H Fernandez, Ramon L Rodriguez, Michael S Okun, Werner Poewe, Gregor K Wenning, John A Hardy, Andrew B Singleton, Francesca Del Sorbo, Susanne Schneider, Kailash P Bhatia, Thomas Gasser.
Abstract
To test whether the synucleinopathies Parkinson's disease and multiple system atrophy (MSA) share a common genetic etiology, we performed a candidate single nucleotide polymorphism (SNP) association study of the 384 most associated SNPs in a genome-wide association study of Parkinson's disease in 413 MSA cases and 3,974 control subjects. The 10 most significant SNPs were then replicated in additional 108 MSA cases and 537 controls. SNPs at the SNCA locus were significantly associated with risk for increased risk for the development of MSA (combined p = 5.5 x 10(-12); odds ratio 6.2) [corrected].Entities:
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Year: 2009 PMID： 19475667 PMCID： PMC3520128 DOI： 10.1002/ana.21685
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422